WFRF:(Heldin Johan)
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- Heldin, JohanUppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmaceutisk cellbiologi och bioteknologi (author)
FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Elsevier BV,2017
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-341984
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341984URI
- https://doi.org/10.1016/j.cellsig.2017.09.009DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The complete repertoire of endothelial functions elicited by FGD5, a guanine nucleotide exchange factor activating the Rho GTPase Cdc42, has yet to be elucidated. Here we explore FGD5's importance during vascular endothelial growth factor A (VEGFA) signaling via VEGF receptor 2 (VEGFR2) in human endothelial cells. In microvascular endothelial cells, FGD5 is located at the inner surface of the cell membrane as well as at the outer surface of EEAl-positive endosomes carrying VEGFR2. The latter finding prompted us to explore if FGD5 regulates VEGFR2 dynamics. We found that depletion of FGD5 in microvascular cells inhibited their migration towards a stable VEGFA gradient. Furthermore, depletion of FGD5 resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 sustains VEGFA signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Angiogenesis
- Cdc42
- FGD5
- Vascular biology
- VEGFR2
- Degradation
Added entries (persons, corporate bodies, meetings, titles ...)
- O'Callaghan, PaulUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)pauoo824 (author)
- Hernández Vera, RodrigoUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)rodhe139 (author)
- Fredlund Fuchs, Peder,1984-Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)pedfu394 (author)
- Gerwins, PärUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)pargerwi (author)
- Kreuger, Johan,1972-Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)jkr07842 (author)
- Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)
Related titles
- In:Cellular Signalling: Elsevier BV40, s. 125-1320898-65681873-3913
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