Use of copeptin for rapid rule-out of acute myocardial infarction

Mueller, ChristianUniv Hosp Basel, Dept Cardiol, Basel, Switzerland; Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland (författare)

Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.

Möckel, MartinCharite Univ Med Berlin, Div Emergency Med, Berlin, Germany (författare)
Giannitsis, EvangelosHeidelberg Univ, Med Klin 3, Heidelberg, Germany (författare)
Huber, KurtWilhelminen Hosp, Dept Med Cardiol & Intens Care Med, Vienna, Austria (författare)
Mair, JohannesInnsbruck Med Univ, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria (författare)
Plebani, MarioUniv Hosp Padova, Dept Lab Med, Padua, Italy (författare)
Thygesen, KristianAarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark (författare)
Jaffe, Allan SMayo Clin, Rochester, MN USA; Med Sch, Rochester, MN USA (författare)
Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR(Swepub:uu)belin227 (författare)
Univ Hosp Basel, Dept Cardiol, Basel, Switzerland; Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, SwitzerlandCharite Univ Med Berlin, Div Emergency Med, Berlin, Germany (creator_code:org_t)

Ingår i:European Heart Journal: Oxford University Press (OUP)7:6, s. 570-5762048-87262048-8734

Av författaren/redakt...: Mueller, Christi ...; Möckel, Martin; Giannitsis, Evan ...; Huber, Kurt; Mair, Johannes; Plebani, Mario; visa fler...; Thygesen, Kristi ...; Jaffe, Allan S; Lindahl, Bertil, ...; visa färre...

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