Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial

Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin : Insights from the ARISTOTLE trial

BACKGROUND: We assessed antiplatelet therapy use and outcomes in patients undergoing percutaneous coronary intervention (PCI) during the ARISTOTLE trial.METHODS: Patients were categorized based on the occurrence of PCI during follow-up (median 1.8 years); PCI details and outcomes post-PCI are reported. Of the 18,201 trial participants, 316 (1.7%) underwent PCI (152 in apixaban group, 164 in warfarin group).RESULTS: inhibitor; 32% received antiplatelet agents without OAC. Post-PCI, patients assigned to apixaban versus warfarin had numerically similar rates of major bleeding (5.93 vs 6.73 events/100 patient-years; P = .95) and stroke (2.74 vs 1.84 events/100 patient-years; P = .62).CONCLUSIONS: PCI occurred infrequently during follow-up. Most patients on study drug at the time of PCI remained on study drug in the peri-PCI period; 19% continued the study drug without interruption. Antiplatelet therapy use post-PCI was variable, although most patients received DAPT. Additional data are needed to guide the use of antithrombotics in patients undergoing PCI.

Jones, W SchuylerDuke University School of Medicine, Durham, USA (författare)
Sherwood, Matthew WInova Heart and Vascular Institute, Fairfax, USA (författare)
Wojdyla, Daniel M (författare)
Wallentin, Lars,1943-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),UCR(Swepub:uu)larswall (författare)
Lewis, Basil SThe Ruth and Bruce Rappaport School of Medicine of the Technion, Haifa, Israel (författare)
Verheugt, Freek W AOnze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, Netherlands (författare)
Vinereanu, DragosUniversity of Medicine and Pharmacy Carol Davila, University and Emergency Hospital of Bucharest, Bucharest, Romania (författare)
Bahit, M CeciliaINECO Neurociencias Oroño, Rosario, Argentina (författare)
Halvorsen, SigrunUniversity of Oslo, Oslo, Norway (författare)
Huber, KurtHospital and Sigmund Freud Private University, Medical School, Vienna, Austria (författare)
Parkhomenko, AlexanderInstitute of Cardiology, Kiev, Ukraine (författare)
Granger, Christopher B (författare)
Lopes, Renato D (författare)
Alexander, John H (författare)
Duke University School of Medicine, Durham, USAInova Heart and Vascular Institute, Fairfax, USA (creator_code:org_t)

Ingår i:American Heart JournalNew York : Elsevier BV197, s. 133-1410002-87031097-6744

Av författaren/redakt...: Kopin, David; Jones, W Schuyle ...; Sherwood, Matthe ...; Wojdyla, Daniel ...; Wallentin, Lars, ...; Lewis, Basil S; visa fler...; Verheugt, Freek ...; Vinereanu, Drago ...; Bahit, M Cecilia; Halvorsen, Sigru ...; Huber, Kurt; Parkhomenko, Ale ...; Granger, Christo ...; Lopes, Renato D; Alexander, John ...; visa färre...

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