Antibodies against MYC-Associated Zinc Finger Protein: An Independent Marker in Acute Coronary Syndrome?

Antibodies against MYC-Associated Zinc Finger Protein : An Independent Marker in Acute Coronary Syndrome?

Introduction: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular, and peripheral vascular diseases. Evidence supporting an autoimmune component is emerging, with imaging studies correlating MYC-associated zinc finger protein antibody (MAZ-Ab) optical density (OD) with plaque activity. This study compares MAZ-Ab OD on ELISA testing among patients presenting with acute coronary syndromes (ACSs) to healthy controls and investigates the association of MAZ-Ab to traditional CVD risk factors.Methods: Patients admitted with ACSs between August 2007 and July 2011 were included. Serum samples taken at presentation were retrospectively tested for MAZ-Ab and compared with serum from healthy volunteers with no CVD risk factors. Large-scale assessment of post-ACS prognostic relevance was performed using the established PLATO cohort.Results: = 0.436).Conclusion: MAZ-Ab OD was higher or all ACS phenotypes compared with controls. Given current understanding of MAZ-Ab function, these findings support an autoimmune component to CVD independent of conventional risk factors and indeed the extent of end-organ damage.

Widera, Christian (författare)
Baerlecken, Niklas T (författare)
Schlumberger, Wolfgang (författare)
Daehnrich, Cornelia (författare)
Schmidt, Reinhold E (författare)
Gabrysch, KatjaUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)kattr302 (författare)
Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall (författare)
Witte, Torsten (författare)
Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Av författaren/redakt...: Ernst, Diana; Widera, Christia ...; Baerlecken, Nikl ...; Schlumberger, Wo ...; Daehnrich, Corne ...; Schmidt, Reinhol ...; visa fler...; Gabrysch, Katja; Wallentin, Lars, ...; Witte, Torsten; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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