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  • Aimo, AlbertoScuola Super Sant Anna, Pisa, Italy (författare)

Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure : An Individual Patient Data Meta-Analysis

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-343493
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343493URI
  • https://doi.org/10.1161/CIRCULATIONAHA.117.031560DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Most patients with chronic heart failure have detectable troponin concentrations when evaluated by high-sensitivity assays. The prognostic relevance of this finding has not been clearly established so far. We aimed to assess high-sensitivity troponin assay for risk stratification in chronic heart failure through a meta-analysis approach.Methods: Medline, EMBASE, Cochrane Library, and Scopus were searched in April 2017 by 2 independent authors. The terms were “troponin” AND “heart failure” OR “cardiac failure” OR “cardiac dysfunction” OR “cardiac insufficiency” OR “left ventricular dysfunction.” Inclusion criteria were English language, clinical stability, use of a high-sensitivity troponin assay, follow-up studies, and availability of individual patient data after request to authors. Data retrieved from articles and provided by authors were used in agreement with the PRISMA statement. The end points were all-cause death, cardiovascular death, and hospitalization for cardiovascular cause.Results: Ten studies were included, reporting data on 11 cohorts and 9289 patients (age 66±12 years, 77% men, 60% ischemic heart failure, 85% with left ventricular ejection fraction <40%). High-sensitivity troponin T data were available for all patients, whereas only 209 patients also had high-sensitivity troponin I assayed. When added to a prognostic model including established risk markers (sex, age, ischemic versus nonischemic etiology, left ventricular ejection fraction, estimated glomerular filtration rate, and N-terminal fraction of pro-B-type natriuretic peptide), high-sensitivity troponin T remained independently associated with all-cause mortality (hazard ratio, 1.48; 95% confidence interval, 1.41–1.55), cardiovascular mortality (hazard ratio, 1.40; 95% confidence interval, 1.33–1.48), and cardiovascular hospitalization (hazard ratio, 1.42; 95% confidence interval, 1.36–1.49), over a median 2.4-year follow-up (all P<0.001). High-sensitivity troponin T significantly improved risk prediction when added to a prognostic model including the variables above. It also displayed an independent prognostic value for all outcomes in almost all population subgroups. The area under the curve–derived 18 ng/L cutoff yielded independent prognostic value for the 3 end points in both men and women, patients with either ischemic or nonischemic etiology, and across categories of renal dysfunction.Conclusions: In chronic heart failure, high-sensitivity troponin T is a strong and independent predictor of all-cause and cardiovascular mortality, and of hospitalization for cardiovascular causes, as well. This biomarker then represents an additional tool for prognostic stratification.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Januzzi, James L,JrMassachusetts Gen Hosp, Boston, MA, USA; Harvard Clin Res Inst, Boston, MA USA (författare)
  • Vergaro, GiuseppeScuola Super Sant Anna, Pisa, Italy; Fdn Toscana Gabriele Monasterio, Pisa, Italy (författare)
  • Ripoli, AndreaFdn Toscana Gabriele Monasterio, Pisa, Italy (författare)
  • Latini, RobertoIRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy (författare)
  • Masson, SergeIRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy (författare)
  • Magnoli, MichelaIRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy (författare)
  • Anand, Inder SUniv Minnesota, Div Cardiovasc Med, Minneapolis, MN, USA; VA Med Ctr, Dept Cardiol, Minneapolis, MN USA (författare)
  • Cohn, Jay NUniv Minnesota, Div Cardiovasc Med, Minneapolis, MN, USA (författare)
  • Tavazzi, LuigiES Hlth Sci Fdn, GVM Hosp Care & Res, Cotignola, Italy (författare)
  • Tognoni, GianniIRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy (författare)
  • Gravning, JørgenOslo Univ Hosp, Dept Cardiol, Ulleval, Norway; Univ Oslo, Ctr Heart Failure Res, Oslo, Norway (författare)
  • Ueland, ThorOslo Univ Hosp, Rikshosp, Internal Med Res Inst, Oslo, Norway; Univ Oslo, Fac Med, Oslo, Norway; Univ Tromso, Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway (författare)
  • Nymo, Ståle HOslo Univ Hosp, Rikshosp, Internal Med Res Inst, Oslo, Norway (författare)
  • Brunner-La Rocca, Hans-PeterMaastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands (författare)
  • Bayes-Genis, AntoniHosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain (författare)
  • Lupón, JosepHosp Badalona Germans Trias & Pujol, Badalona, Barcelona, Spain (författare)
  • de Boer, Rudolf AUniv Groningen, Univ Med Ctr Groningen, Groningen, Netherlands (författare)
  • Yoshihisa, AkiomiFukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan (författare)
  • Takeishi, YasuchikaFukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan (författare)
  • Egstrup, MichaelCopenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark (författare)
  • Gustafsson, IdaCopenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark (författare)
  • Gaggin, Hanna KMassachusetts Gen Hosp, Boston, MA, USA; Harvard Clin Res Inst, Boston, MA, USA (författare)
  • Eggers, Kai M.,1962-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)kaieg561 (författare)
  • Huber, KurtWilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria (författare)
  • Tentzeris, IoannisWilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria (författare)
  • Tang, Wai H.W.Cleveland Clin, Inst Heart & Vasc, Cleveland, OH, USA (författare)
  • Grodin, JustinUniv Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA (författare)
  • Passino, ClaudioScuola Super Sant Anna, Pisa, Italy; Fdn Toscana Gabriele Monasterio, Pisa, Italy (författare)
  • Emdin, MicheleScuola Super Sant Anna, Pisa, Italy; Fdn Toscana Gabriele Monasterio, Pisa, Italy (författare)
  • Scuola Super Sant Anna, Pisa, ItalyMassachusetts Gen Hosp, Boston, MA, USA; Harvard Clin Res Inst, Boston, MA USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Circulation137:3, s. 286-2970009-73221524-4539

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