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  • Sclafani, FrancescoRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-23
  • Springer Science and Business Media LLC,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-343671
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343671URI
  • https://doi.org/10.1038/s41598-018-19212-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There are limited data on circulating, cell-free, tumour (ct) DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd) PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX +/- cetuximab in a randomised phase II trial. KRAS mutation in G12D, G12V or G13D was detected in the ctDNA of 43% and 35% of patients with tumours that were mutant and wild-type for these hotspot mutations, respectively, according to standard PCR-based analyses on tissue. The detection rate in the ctDNA of 10 patients with less common mutations was 50%. In 26 cases ctDNA analysis revealed KRAS mutations that were not previously found in tissue. Twenty-two of these (84.6%) were detected following repeat tissue testing by ddPCR. Overall, the ctDNA detection rate in the KRAS mutant population was 66%. Detection of KRAS mutation in ctDNA failed to predict prognosis or refine patient selection for cetuximab. While this study confirms the feasibility of ctDNA analysis in LARC and the high sensitivity of ddPCR, larger series are needed to better address the role of ctDNA as a prognostic or predictive tool in this setting.

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  • Chau, IanRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Cunningham, DavidRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Hahne, Jens C.Inst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Vlachogiannis, GeorgeInst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Eltahir, ZakariaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Lampis, AndreaInst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Braconi, ChiaraRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England.;Inst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Kalaitzaki, EleftheriaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • De Castro, David GonzalezRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Wotherspoon, AndrewRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Capdevila, JaumeUniv Autonoma Barcelona, Vall dHebron Univ Hosp, Barcelona, Spain. (author)
  • Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim (author)
  • Tarazona, NoeliaUniv Valencia, Biomed Res Inst INCLIVA, Valencia, Spain. (author)
  • Begum, RuwaidaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Lote, HazelRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England.;Inst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Wilson, Sanna HulkkiRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Mentrasti, GiuliaInst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Brown, GinaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Tait, DianaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Oates, JacquelineRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England. (author)
  • Valeri, NicolaRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England.;Inst Canc Res, London, England.;Inst Canc Res, Surrey, England. (author)
  • Royal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Surrey, England.Inst Canc Res, London, England.;Inst Canc Res, Surrey, England. (creator_code:org_t)

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  • In:Scientific Reports: Springer Science and Business Media LLC82045-2322

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