Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project

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Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis : a European registries collaborative project

Mercer, Louise K. (författare): Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England.

Regierer, Anne C. (författare): German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany.

Mariette, Xavier (författare): Univ Paris Sud, Hop Univ Paris Sud, Dept Rheumatol, Le Kremlin Bicetre, France.

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Dixon, William G. (författare): Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England.

Baecklund, Eva, 1956- (författare): Uppsala universitet,Reumatologi

Hellgren, Karin (författare): Karolinska Institutet

Dreyer, Lene (författare): Rigshosp, Gentofte Univ Hosp, Ctr Rheumatol & Spine Dis, Hellerup, Denmark.;Parker Inst, Frederiksberg, Denmark.

Hetland, Merete Lund (författare): Rigshosp, Ctr Head & Orthopaed, Copenhagen Ctr Arthrit Res, DANBIO, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.

Cordtz, Rene (författare): Rigshosp, Gentofte Univ Hosp, Ctr Rheumatol & Spine Dis, Hellerup, Denmark.;Parker Inst, Frederiksberg, Denmark.

Hyrich, Kimme (författare): Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci, Natl Inst Hlth Res Manchester, Musculoskeletal Biomed Res Unit, Manchester, Lancs, England.

Strangfeld, Anja (författare): German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany.

Zink, Angela (författare): German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany.;Charite, Berlin, Germany.

Canhao, Helena (författare): Univ Nova Lisboa, EpiDoC Unit, CEDOC, NOVA Med Sch, Lisbon, Portugal.;Natl Sch Publ Hlth, Lisbon, Portugal.

Victoria Hernandez, M. (författare): Hosp Clin Barcelona, Dept Rheumatol, Barcelona, Spain.

Tubach, Florence (författare): Univ Paris 06, Sorbonne Univ, Hop Pitie Salpetriere, AP HP,Dept BIOSPIM, Paris, France.

Gottenberg, Jacques-Eric (författare): CHU Strasbourg, Dept Rheumatol, Strasbourg, France.

Morel, Jacques (författare): Univ Montpellier, Dept Rheumatol, Montpellier, France.;Teaching Hosp Lapeyronie, Montpellier, France.

Zavada, Jakub (författare): Charles Univ Prague, Fac Med 1, Inst Rheumatol, Prague, Czech Republic.

Iannone, Florenzo (författare): Univ Bari, Rheumatol Unit, Bari, Italy.

Askling, Johan (författare): Karolinska Institutet

Listing, Joachim (författare): German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany.

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Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany. (creator_code:org_t)

2017-08-19
2017
Engelska.
Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:12, s. 2025-2030

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://ard.bmj.com/...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Background Lymphomas comprise a heterogeneous group of malignant diseases with highly variable prognosis. Rheumatoid arthritis (RA) is associated with a twofold increased risk of both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). It is unknown whether treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) affect the risk of specific lymphoma subtypes.Methods Patients never exposed to (bionaïve) or ever treated with bDMARDs from 12 European biologic registers were followed prospectively for the occurrence of first ever histologically confirmed lymphoma. Patients were considered exposed to a bDMARD after having received the first dose. Lymphomas were attributed to the most recently received bDMARD.Results Among 124 997 patients (mean age 59 years; 73.7% female), 533 lymphomas were reported. Of these, 9.5% were HL, 83.8% B-cell NHL and 6.8% T-cell NHL. No cases of hepatosplenic T-cell lymphoma were observed. Diffuse large B-cell lymphoma (DLBCL) was the most frequent B-cell NHL subtype (55.8% of all B-cell NHLs). The subtype distributions were similar between bionaïve patients and those treated with tumour necrosis factor inhibitors (TNFi). For other bDMARDs, the numbers of cases were too small to draw any conclusions. Patients with RA developed more DLBCLs and less chronic lymphocytic leukaemia compared with the general population.Conclusion This large collaborative analysis of European registries has successfully collated subtype information on 533 lymphomas. While the subtype distribution differs between RA and the general population, there was no evidence of any modification of the distribution of lymphoma subtypes in patients with RA treated with TNFi compared with bionaïve patients.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

Artiklar i publikationen: Annals of the Rh ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis : a European registries collaborative project

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