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Search: WFRF:(Van Vollenhoven Ronald F.) > (2015-2019) > Dietary Intake of P...

  • Lourdudoss, Cecilia (author)

Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients.

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-29
  • Wiley,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-344283
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-344283URI
  • https://doi.org/10.1002/acr.23245DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137507373URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: To investigate potential associations between dietary intake of polyunsaturated fatty acids (FAs) and pain patterns in early rheumatoid arthritis (RA) patients after 3 months of methotrexate (MTX) treatment.METHODS: We included 591 early RA patients with MTX monotherapy from a population-based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis. Dietary data on polyunsaturated FAs (food frequency questionnaires) were linked with data on unacceptable pain (visual analog scale [VAS] >40 mm), noninflammatory/refractory pain (VAS >40 mm and C-reactive protein [CRP] level <10 mg/liter), and inflammatory pain (VAS >40 mm and CRP level >10 mg/liter) after 3 months. Statistical analysis included logistic regression.RESULTS: After 3 months of MTX treatment, 125 patients (21.2%) had unacceptable pain, of which 92 patients had refractory pain, and 33 patients had inflammatory pain. Omega-3 FA intake was inversely associated with unacceptable pain and refractory pain (odds ratio [OR] 0.57 [95% confidence interval (95% CI) 0.35-0.95] and OR 0.47 [95% CI 0.26-0.84], respectively). The omega-6:omega-3 FA ratio, but not omega-6 FA alone, was directly associated with unacceptable pain and refractory pain (OR 1.70 [95% CI 1.03-2.82] and OR 2.33 [95% CI 1.28-4.24], respectively). Furthermore, polyunsaturated FAs were not associated with either inflammatory pain or CRP level and erythrocyte sedimentation rate at followup. Omega-3 FA supplementation was not associated with any pain patterns.CONCLUSION: Omega-3 FA was inversely associated with, and the omega-6:omega-3 FA ratio was directly associated with, unacceptable and refractory pain, but not with inflammatory pain or systemic inflammation. The inverse association between omega-3 FA and refractory pain may have a role in pain suppression in RA.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Di Giuseppe, DanielaKarolinska Institutet (author)
  • Wolk, AlicjaKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden(Swepub:uu)alwol516 (author)
  • Westerlind, HelgaKarolinska Institutet (author)
  • Klareskog, LarsKarolinska Institutet (author)
  • Alfredsson, LarsKarolinska Institutet (author)
  • van Vollenhoven, Ronald FKarolinska Institutet (author)
  • Lampa, JonKarolinska Institutet (author)
  • Karolinska InstitutetKarolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Arthritis care & research: Wiley70:2, s. 205-2122151-464X2151-4658

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