id:"swepub:oai:DiVA.org:uu-344303"
Sökning: id:"swepub:oai:DiVA.org:uu-344303" > Equine in vivo-deri...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Hansson, AnnelieUppsala universitet,Analytisk vetenskap (författare)
Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites.
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- Elsevier BV,2018
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-344303
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-344303URI
- https://doi.org/10.1016/j.jchromb.2017.12.010DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- LGD-4033 has been found in human doping control samples and has the potential for illicit use in racehorses as well. It belongs to the pharmacological class of selective androgen receptor modulators (SARMs) and can stimulate muscle growth, much like anabolic steroids. However, SARMs have shown superior side effect profiles compared to anabolic steroids, which arguably makes them attractive for use by individuals seeking an unfair advantage over their competitors. The purpose of this study was to investigate the metabolites formed from LGD-4033 in the horse in order to find suitable analytical targets for doping controls. LGD-4033 was administered to three horses after which plasma and urine samples were collected and analyzed for metabolites using ultra high performance liquid chromatography coupled to a high resolution mass spectrometer. In horse urine, eight metabolites, both phase I and phase II, were observed most of which had not been described in other metabolic systems. Six of these were also detected in plasma. The parent compound was detected in plasma, but not in non-hydrolyzed urine. The longest detection times were observed for unchanged LGD-4033 in plasma and in urine hydrolyzed with β-glucuronidase and is thus suggested as the analytical target for doping control in the horse. The metabolite profile determined in the horse samples was also compared to those of human urine and fungal incubate from Cunninghamella elegans. The main human metabolite, dihydroxylated LGD-4033, was detected in the horse samples and was also produced by the fungus. However, it was a not a major metabolite for horse and fungus, which highlights the importance of performing metabolism studies in the species of interest.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
- Doping
- LGD-4033
- Horse
- Mass Spectrometry
- Metabolite
- SARM
- Selective Androgen Receptor Modulator
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Knych, Heather (författare)
- Stanley, Scott (författare)
- Berndtson, EmmaUppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden (författare)
- Jackson, LioraUppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden (författare)
- Bondesson, UlfUppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden(Swepub:uu)ulfbonde (författare)
- Thevis, Mario (författare)
- Hedeland, MikaelUppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden(Swepub:uu)mikahede (författare)
- Uppsala universitetAnalytisk vetenskap (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of chromatography. B: Elsevier BV1074-1075, s. 91-981570-02321873-376X
Internetlänk
Hitta via bibliotek
- Journal of chromatography. B (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Hansson, Annelie
- Knych, Heather
- Stanley, Scott
- Berndtson, Emma
- Jackson, Liora
- Bondesson, Ulf
- visa fler...
- Thevis, Mario
- Hedeland, Mikael
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Läkemedelskemi
- Artiklar i publikationen
- Journal of chrom ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
