Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

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Ehrhardt, CarstenTrinity Coll Dublin, Trinity Biomed Sci Inst, Sch Pharm & Pharmaceut Sci, Dublin, Ireland. (författare)

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs : Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin hosted the "1st Workshop on Drug Transporters in the Lungs" in September 2016 to discuss the impact of transporters on pulmonary drug disposition and their roles as drug targets in lung disease. The workshop brought together about 30 scientists from academia and pharmaceutical industry from Europe and Japan and addressed the primary questions: What do we know today, and what do we need to know tomorrow about transporters in the lung? The 3 themes of the workshop were: (1) techniques to study drug transporter expression and actions in the lungs; (2) drug transporter effects on pulmonary pharmacokinetics-case studies; and (3) transporters as drug targets in lung disease. Some of the conclusions of the workshop were: suitable experimental models that allow studies of transporter effects are available; data from these models convincingly show a contribution of both uptake and efflux transporters on pulmonary drug disposition; the effects of transporters on drug lung PK is now better conceptualized; some transporters are associated with lung diseases. However, more work is needed to establish which of the available models best translate to the clinical situation.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
absorption
computational ADME
efflux pumps
in vitro models
organic cation transporters
P-glycoprotein
peptide transporters
pulmonary delivery/absorption
ABC transporters
organic anion-transporting polypeptide transporters

Backman, PerMylan Global Resp Grp, Sandwich, Kent, England. (författare)
Couet, WilliamUniv Poitiers, CHU Poitiers, UFR Med Pharm, Inserm,U1070, Poitiers, France. (författare)
Edwards, ChrisGlaxoSmithKline Medicines Res Ctr, Refractory Resp Inflammat DPU, Stevenage, Herts, England. (författare)
Forbes, BenKings Coll London, Inst Pharmaceut Sci, London, England. (författare)
Fridén, MarkusUppsala universitet,Institutionen för farmaceutisk biovetenskap,AstraZeneca R&D Gothenburg, Resp Inflammat & Autoimmun Innovat Med, Molndal, Sweden.,Translationell PKPD(Swepub:uu)mafri535 (författare)
Gumbleton, MarkCardiff Univ, Sch Pharm & Pharmaceut Sci, Expt Therapeut, Cardiff, S Glam, Wales. (författare)
Hosoya, Ken-IchiToyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Pharmaceut, Toyama, Japan. (författare)
Kato, YukioKanazawa Univ, Fac Pharmaceut Sci, Dept Mol Pharmacotherapeut, Kanazawa, Ishikawa, Japan. (författare)
Nakanishi, TakeoKanazawa Univ, Fac Pharmaceut Sci, Dept Membrane Transport & Biopharmaceut, Kanazawa, Ishikawa, Japan. (författare)
Takano, MikihisaHiroshima Univ, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan. (författare)
Terasaki, TetsuyaTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan. (författare)
Yumoto, RyokoHiroshima Univ, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan. (författare)
Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Pharm & Pharmaceut Sci, Dublin, Ireland.Mylan Global Resp Grp, Sandwich, Kent, England. (creator_code:org_t)

Ingår i:Journal of Pharmaceutical Sciences: Elsevier BV106:9, s. 2234-22440022-35491520-6017

Av författaren/redakt...: Ehrhardt, Carste ...; Backman, Per; Couet, William; Edwards, Chris; Forbes, Ben; Fridén, Markus; visa fler...; Gumbleton, Mark; Hosoya, Ken-Ichi; Kato, Yukio; Nakanishi, Takeo; Takano, Mikihisa; Terasaki, Tetsuy ...; Yumoto, Ryoko; visa färre...

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