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Spermatogonia Loss ...
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation
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- Kurek, Magdalena (författare)
- Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Åkesson, Elisabet (författare)
- Karolinska Institutet,Karolinska Institute,Stockholms Sjukhem Foundation,Division of Neurogeriatrics, Department of Neurobiology Care Sciences & Society, Karolinska Institutet, Huddinge, Sweden; R & D Unit, Stockholms Sjukhem, 112 19 Stockholm, Sweden
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- Yoshihara, Masahito (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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- Oliver, Elizabeth (författare)
- Karolinska Institutet,Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Cui, Yanhua (författare)
- Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Becker, Martin (författare)
- Karolinska Institutet,Karolinska Institute,Center of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Karolinska Institutet, Centre for Psychiatry Research, Region Stockholm and Astrid Lindgren Children's Hospital, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Univ Hosp, Sweden
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- Alves-Lopes, João Pedro (författare)
- Karolinska Institutet,Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Henry Wellcome Bldg Canc & Dev Biol, England
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- Bjarnason, Ragnar (författare)
- National University Hospital of Iceland,Children's Medical Center, Landspítali University Hospital, Reykjavik, Iceland; Department of Paediatrics Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Landspitali Univ Hosp, Iceland; Univ Iceland, Iceland
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- Romerius, Patrik (författare)
- Lund University,Lunds universitet,Cancercellers evolution,Forskargrupper vid Lunds universitet,Pathways of cancer cell evolution,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden,Department of Paediatric Oncology and Haematology, Clinical Sciences, Lund University, Skånes Universitetssjukhus, Lund, Sweden
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- Sundin, Mikael (författare)
- Karolinska Institutet,Karolinska Institute,Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Sweden; Pediatric Blood Disorders, Immunodeficiency and Stem Cell Transplantation Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Huddinge, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Norén-Nyström, Ulrika (författare)
- Umeå universitet,Umeå University,Umea Univ, Sweden,Pediatrik
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- Langenskiöld, Cecilia (författare)
- Department of Paediatric Oncology, Queen Silvia Children's Hospital, Gothenburg, Sweden,Queen Silvia Childrens Hosp, Sweden
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- Vogt, Hartmut (författare)
- Linköpings universitet,Linköping University,Crown Princess Victoria's Child and Youth Hospital, Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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- Henningsohn, Lars (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden,Division of Urology, Institution for Clinical Science Intervention and Technology, Karolinska Institutet, Huddinge, Sweden
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- Petersen, Cecilia (författare)
- Karolinska Institutet,Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Söder, Olle (författare)
- Karolinska Institutet,Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Guo, Jingtao (författare)
- Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, United States,Univ Utah, UT 84112 USA
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- Mitchell, Rod T. (författare)
- MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Edinburgh Royal Hospital for Sick Children, Edinburgh, United Kingdom,University of Edinburgh,Univ Edinburgh, Scotland; Edinburgh Royal Hosp Sick Children, Scotland
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- Jahnukainen, Kirsi (författare)
- Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden; Division of Haematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland,Helsinki University Central Hospital,University of Helsinki,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Univ Helsinki, Finland
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- Stukenborg, Jan Bernd (författare)
- Karolinska Institutet,Karolinska Institute,NORDFERTIL Research Lab Stockholm, Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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(creator_code:org_t)
- 2021-01-27
- 2021
- Engelska.
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Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 10:2
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://www.mdpi.com...
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https://liu.diva-por... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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http://kipublication...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can be observed in human testicular explant cultures, germ cell depletion is a common obstacle. Hence, understanding the spermatogonial stem cell (SSC) niche environment and in particular, specific components such as the seminiferous basement membrane (BM) will allow progression of testicular explant cultures. Here, we revealed that the seminiferous BM is established from 6 weeks post conception with the expression of laminin alpha 1 (LAMA 1) and type IV collagen, which persist as key components throughout development. With prepubertal testicular explant culture we found that seminiferous LAMA 1 expression is disrupted and depleted with culture time correlating with germ cell loss. These findings highlight the importance of LAMA 1 for the human SSC niche and its sensitivity to culture conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- basal membrane
- germ cells
- infertility
- late effects
- seminiferous tubules
- Sertoli cells
- spermatogonia
- stem cell niche
- germ cells; basal membrane; stem cell niche; seminiferous tubules; infertility; late effects; spermatogonia; Sertoli cells
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Kurek, Magdalena
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Åkesson, Elisabe ...
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Yoshihara, Masah ...
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Oliver, Elizabet ...
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Cui, Yanhua
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Becker, Martin
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visa fler...
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Alves-Lopes, Joã ...
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Bjarnason, Ragna ...
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Romerius, Patrik
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Sundin, Mikael
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Norén-Nyström, U ...
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Langenskiöld, Ce ...
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Vogt, Hartmut
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Henningsohn, Lar ...
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Petersen, Cecili ...
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Söder, Olle
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Guo, Jingtao
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Mitchell, Rod T.
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Jahnukainen, Kir ...
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Stukenborg, Jan ...
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