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Association of MMP-...
Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients
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- Chan, Owen T. M. (författare)
- Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA.
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- Furuya, Hideki (författare)
- Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA.
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- Pagano, Ian (författare)
- Univ Hawaii, Ctr Canc, Canc Prevent & Control Program Res Program, Honolulu, HI 96822 USA.
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- Shimizu, Yoshiko (författare)
- Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA.;Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA.
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- Hokutan, Kanani (författare)
- Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA.;Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA.
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- Dyrskjot, Lars (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
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- Jensen, Jorgen Bjerggaard (författare)
- Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark.
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- Malmström, Per-Uno (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Segersten, Ulrika (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Janku, Filip (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA.
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- Rosser, Charles J. (författare)
- Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA.
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Univ Hawaii, Ctr Canc, Clin & Translat Res Program, Honolulu, HI 96822 USA Univ Hawaii, Ctr Canc, Canc Prevent & Control Program Res Program, Honolulu, HI 96822 USA. (creator_code:org_t)
- 2017-09-06
- 2017
- Engelska.
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:59, s. 99707-99721
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: We previously reported an accurate urine-based bladder cancer (BCa)-associated diagnostic signature that can be used to non-invasively detect BCa. In this study, we investigated whether a component of this signature could risk stratify patients with BCa. Methods: Utilizing immunohistochemistry, we investigated angiogenin, MMP-2, p53, RB and PAI-1 expression from 939 patients with BCa. The expression levels were scored by assigning a proportion score and an intensity score to yield a total staining score for each protein. The expressions of each protein individually and as an aggregate were then correlated with progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). Results: Differential expressions of these markers were noted in BCa. With multivariate analysis in non-muscle invasive bladder cancer (NMIBC) age, tumor grade portended a worse PFS, while age, tumor grade, nodal status, MMP2, RB and PAI-1 expression portended a worse OS. As for multivariate analysis in muscle invasive bladder cancer (MIBC), age MMP-2 and RB were associated with a worse PFS, while age, nodal status, MMP-2, RB and PAI-1 were associated with a worse OS. Using Kaplan-Meier survival analysis, we noted a significant reduction in OS as more of the five biomarkers were expressed in a tumor. Thus, overall, high expressions of MMP-2, RB and/or PAI-1 in bladder tumors were markers of poor prognosis. Conclusion: Individually, MMP-2, RB and PAI-1, as well as in aggregate correlated with poor survival in patients with BCa. Thus, patients whose bladder tumors express these biomarkers may benefit from early radical treatment and/or neoadjuvant or adjuvant therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- angiogenin
- bladder cancer
- IHC
- MMP-2
- PAI-1
- survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Chan, Owen T. M.
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Furuya, Hideki
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Pagano, Ian
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Shimizu, Yoshiko
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Hokutan, Kanani
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Dyrskjot, Lars
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Jensen, Jorgen B ...
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Malmström, Per-U ...
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Segersten, Ulrik ...
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Janku, Filip
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Rosser, Charles ...
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Oncotarget
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Uppsala universitet