Long-term survival after treatment for primary anal cancer– results from the Swedish national ANCA cohort study

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Fältnamn	Indikatorer	Metadata
000		03944naa a2200373 4500
001		oai:gup.ub.gu.se/314501
003		SwePub
008		240528s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3145012 URI
024	7	a https://doi.org/10.1080/0284186X.2022.20333142 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Johansson, Mia,d 19774 aut
245	1 0	a Long-term survival after treatment for primary anal cancer– results from the Swedish national ANCA cohort study
264	1	c 2022
520		a Background: Squamous cell carcinoma of the anus is increasing in incidence but remains a rare disease with good 3- and 5-year recurrence free and overall survival rates of 63%–86%. The treatment includes chemoradiotherapy, mainly with 5-fluoruracil (5FU) and mitomycin. The aim of this study was to describe long-term (up to 9years after treatment) oncological outcome and the types of treatments given, in a Swedish national cohort of patients diagnosed with anal cancer between 2011 and 2013. Method: Patients were identified in the Swedish Cancer Registry. Patients still alive were contacted and asked for consent. Clinical data were retrieved from National Patient Register at the Swedish National Board of Health and Welfare and from medical records. Unadjusted and adjusted analyses were performed for overall survival. Results: Three hundred and eighty-eight patients were included in the study of which 338 patients (87%) received treatment with a curative intent. Follow up was 85months (0–113months) for patients treated with curative intent (information missing in one patient) 7.5months (0–55) for patients with treated with a palliative intent. Curative treatment varied and consisted of both chemoradiotherapy and radiotherapy (46–64 Gy) alone. 5-FU, mitomycin and cisplatin were the most used chemotherapy agents. Five-year overall survival for patients treated with curative intent was 73%. In an adjusted analysis 5-FU and mitomycin is associated with a lower mortality than 5-FU and cisplatin but the association was weaker (HR 1.61 (95% CI: 0.904; 2.85) than in the unadjusted analysis Conclusions: In this national cohort overall five-year survival was 73% for patients treated with curative intent. As reported by others our results indicate that 5-FU and mitomycin C should be the preferred chemotherapy in treatment for cure. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Anal cancer
653		a chemoradiotherapy
653		a chemotherapy
653		a radiotherapy
653		a survival
700	1	a Axelsson, Annau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xaxanc
700	1	a Haglind, E.4 aut
700	1	a Bock, David,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xbocda
700	1	a Angenete, Eva,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xangee
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för kirurgi4 org
773	0	t Acta Oncologicag 61:4, s. 478-83q 61:4<478-83x 0284-186X
856	4 8	u https://gup.ub.gu.se/publication/314501
856	4 8	u https://doi.org/10.1080/0284186X.2022.2033314

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Av författaren/redakt...: Johansson, Mia, ...; Axelsson, Anna; Haglind, E.; Bock, David, 197 ...; Angenete, Eva, 1 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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