Search: WFRF:(Ferraz Natalia 1976 ) >
Blood Compatibility...
Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads
-
- Rocha, Igor (author)
- Uppsala universitet,Nanoteknologi och funktionella material,CAPES Foundation, Ministry of Education of Brazil, Brasília, DF 70040-020, Brazil
-
- Lindh, Jonas, 1977- (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
-
- Hong, Jaan (author)
- Uppsala universitet,Klinisk immunologi
-
show more...
-
- Strömme, Maria, 1970- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
-
- Mihranyan, Albert, 1978- (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
-
- Ferraz, Natalia, 1976- (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
-
show less...
-
(creator_code:org_t)
- 2018-03-07
- 2018
- English.
-
In: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 23:3
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Sulfonated cellulose beads were prepared by oxidation of Cladophora nanocellulose to 2,3-dialdehyde cellulose followed by sulfonation using bisulfite. The physicochemical properties of the sulfonated beads, i.e., high surface area, high degree of oxidation, spherical shape, and the possibility of tailoring the porosity, make them interesting candidates for the development of immunosorbent platforms, including their application in extracorporeal blood treatments. A desired property for materials used in such applications is blood compatibility; therefore in the present work, we investigate the hemocompatibility of the sulfonated cellulose beads using an in vitro whole blood model. Complement system activation (C3a and sC5b-9 levels), coagulation activation (thrombin-antithrombin (TAT) levels) and hemolysis were evaluated after whole blood contact with the sulfonated beads and the results were compared with the values obtained with the unmodified Cladophora nanocellulose. Results showed that neither of the cellulosic materials presented hemolytic activity. A marked decrease in TAT levels was observed after blood contact with the sulfonated beads, compared with Cladophora nanocellulose. However, the chemical modification did not promote an improvement in Cladophora nanocellulose hemocompatibility in terms of complement system activation. Even though the sulfonated beads presented a significant reduction in pro-coagulant activity compared with the unmodified material, further modification strategies need to be investigated to control the complement activation by the cellulosic materials.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- sulfonated beads; Cladophora nanocellulose; hemocompatibility; coagulation; complement system
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Molecules
(Search for host publication in LIBRIS)
To the university's database