Sökning: L773:2162 4011 OR L773:2162 402X
> (2015-2019) >
Cancer vaccine base...
Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
-
- Fotaki, Grammatiki (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
-
- Jin, Chuan, 1986- (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Kerzeli, Iliana Kyriaki (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
visa fler...
-
- Ramachandran, Mohanraj, 1988- (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Martikainen, Minttu-Maria (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
-
- Karlsson-Parra, Alex (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab,Immunicum AB, Gothenburg
-
- Yu, Di, 1985- (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Essand, Magnus (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
visa färre...
-
(creator_code:org_t)
- 2018
- 2018
- Engelska.
-
Ingår i: Oncoimmunology. - 2162-4011 .- 2162-402X. ; 7:3
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Autologous patient-derived dendritic cells (DCs) modified ex vivo to present tumor-associated antigens (TAAs) are frequently used as cancer vaccines. However, apart from the stringent logistics in producing DCs on a patient basis, accumulating evidence indicate that ex vivo engineered DCs are poor in migration and in fact do not directly present TAA epitopes to naïve T cells in vivo. Instead, it is proposed that bystander host DCs take up material from vaccine-DCs, migrate and subsequently initiate antitumor T-cell responses. We used mouse models to examine the possibility of using pro-inflammatory allogeneic DCs (alloDCs) to activate host DCs and enable them to promote antigen-specific T-cell immunity. We found that alloDCs were able to initiate host DC activation and migration to draining lymph node leading to T-cell activation. The pro-inflammatory milieu created by alloDCs also led to recruitment of NK cells and neutrophils at the site of injection. Vaccination with alloDCs combined with Ad5M(gp100), an infection-enhanced adenovirus encoding the human melanoma-associated antigen gp100 resulted in generation of CD8+ T cells with a T-cell receptor (TCR) specific for the gp10025-33 epitope (gp100-TCR+). Ad5M(gp100)-alloDC vaccination in combination with transfer of gp100-specific pmel-1 T cells resulted in prolonged survival of B16-F10 melanoma-bearing mice and altered the composition of the tumor microenvironment (TME). We hereby propose that alloDCs together with TAA- or neoepitope-encoding Ad5M can become an “off-the-shelf” cancer vaccine, which can reverse the TME-induced immunosuppression and induce host cellular anti-tumor immune responses in patients without the need of a time-consuming preparation step of autologous DCs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- adjuvants
- Allogeneic dendritic cells
- cell-based immunotherapy
- tumor microenvironment
- tumor-associated antigen
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Fotaki, Grammati ...
-
Jin, Chuan, 1986 ...
-
Kerzeli, Iliana ...
-
Ramachandran, Mo ...
-
Martikainen, Min ...
-
Karlsson-Parra, ...
-
visa fler...
-
Yu, Di, 1985-
-
Essand, Magnus
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Oncoimmunology
- Av lärosätet
-
Uppsala universitet