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Nucleases as molecu...
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Balian, AlienLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
(author)
Nucleases as molecular targets for cancer diagnosis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-11-22
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BMC,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-181677
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-181677URI
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https://doi.org/10.1186/s40364-021-00342-4DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Funding Agencies|Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation; Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]; Linkoping University
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Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.
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Hernandez, FrankLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)frahe49
(author)
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Linköpings universitetMolekylär ytfysik och nanovetenskap
(creator_code:org_t)
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In:Biomarker Research: BMC9:12050-7771
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