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Long-Term Outcomes ...
Long-Term Outcomes Among 2-Year Survivors of Autologous Hematopoietic Cell Transplantation for Hodgkin and Diffuse Large B-Cell Lymphoma
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- Myers, Regina M. (författare)
- Childrens Hosp Philadelphia, Div Hematol & Oncol, Philadelphia, PA 19104 USA.
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- Hill, Brian T. (författare)
- Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA.
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- Shaw, Bronwen E. (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Kim, Soyoung (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI 53226 USA.
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- Millard, Heather R. (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Battiwalla, Minoo (författare)
- NHLBI, Hematol Branch, Bethesda, MD 20892 USA.
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- Majhail, Navneet S. (författare)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Buchbinder, David (författare)
- Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA.
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- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA.
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Flowers, Mary E. D. (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
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- D'Souza, Anita (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Ehrhardt, Matthew J. (författare)
- St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA.
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- Langston, Amelia (författare)
- Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.
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- Yared, Jean A. (författare)
- Univ Maryland, Dept Med, Div Hematol Oncol, Greenebaum Comprehens Canc Ctr,Blood & Marrow Tra, Baltimore, MD 21201 USA.
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- Hayashi, Robert J. (författare)
- Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA.
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- Daly, Andrew (författare)
- Tom Baker Canc Clin, Calgary, AB, Canada.
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden
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- Inamoto, Yoshihiro (författare)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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- Malone, Adriana K. (författare)
- Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
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- DeFilipp, Zachariah (författare)
- Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.
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- Margossian, Steven P. (författare)
- Boston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA.
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- Warwick, Anne B. (författare)
- Uniformed Serv Ind Hlth Sci, Dept Pediat, Bethesda, MD USA.
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- Jaglowski, Samantha (författare)
- Ohio State Univ, Med Ctr, Div Hematol, Columbus, OH 43210 USA.
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- Beitinjaneh, Amer (författare)
- Univ Miami, Miami, FL USA.
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- Fung, Henry (författare)
- Fox Chase Canc Ctr, Dept Med Oncol, 7701 Burholme Ave, Philadelphia, PA 19111 USA.
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- Kasow, Kimberly A. (författare)
- Univ N Carolina, Div Hematol Oncol, Dept Pediat, Chapel Hill, NC USA.
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- Marks, David I. (författare)
- Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.
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- Reynolds, Jana (författare)
- Baylor Univ, Med Ctr, Dallas, TX USA.
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- Stockerl-Goldstein, Keith (författare)
- Washington Univ, Sch Med, Div Oncol, St Louis, MO USA.
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- Wirk, Baldeep (författare)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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- Wood, William A. (författare)
- Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC USA.
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- Hamadani, Mehdi (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Satwani, Prakash (författare)
- Columbia Univ, Med Ctr, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY USA.
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Childrens Hosp Philadelphia, Div Hematol & Oncol, Philadelphia, PA 19104 USA Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA. (creator_code:org_t)
- 2017-11-10
- 2018
- Engelska.
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 124:4, s. 816-825
- Relaterad länk:
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https://acsjournals....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Autologous hematopoietic cell transplantation (auto-HCT) is a standard therapy for relapsed classic Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL); however, long-term outcomes are not well described.METHODS: This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression-free for >= 2 years after auto-HCT for cHL or DLBCL between 1990 and 2008. The median age at auto-HCT was 40 years; the median follow-up was 10.6 years.RESULTS: The 5-year overall survival rate was 90% (95% confidence interval [CI], 87%-92%) for patients with cHL and 89% (95% CI, 87%-91%) for patients with DLBCL. The risk of late mortality in comparison with the general population was 9.6-fold higher for patients with cHL (standardized mortality ratio [SMR], 9.6) and 3.4-fold higher for patients with DLBCL (SMR, 3.4). Relapse accounted for 44% of late deaths. At least 1 late effect was reported for 9% of the patients. A total of 105 SMNs were confirmed: 44 in the cHL group and 61 in the DLBCL group. According to a multivariate analysis, older age, male sex, a Karnofsky score < 90, total body irradiation (TBI) exposure, and a higher number of lines of chemotherapy before auto-HCT were risk factors for overall mortality in cHL. Risk factors in DLBCL were older age and TBI exposure. A subanalysis of 798 adolescent and young adult patients mirrored the outcomes of the overall study population.CONCLUSIONS: Despite generally favorable outcomes, 2-year survivors of auto-HCT for cHL or DLBCL have an excess late-mortality risk in comparison with the general population and experience an assortment of late complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- autologous hematopoietic cell transplant
- diffuse large B-cell lymphoma
- Hodgkin lymphoma
- late effects
- nonrelapse mortality
- survival
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- Av författaren/redakt...
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Myers, Regina M.
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Hill, Brian T.
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Shaw, Bronwen E.
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Kim, Soyoung
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Millard, Heather ...
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Battiwalla, Mino ...
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visa fler...
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Majhail, Navneet ...
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Buchbinder, Davi ...
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Lazarus, Hillard ...
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Savani, Bipin N.
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Flowers, Mary E. ...
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D'Souza, Anita
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Ehrhardt, Matthe ...
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Langston, Amelia
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Yared, Jean A.
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Hayashi, Robert ...
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Daly, Andrew
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Olsson, Richard
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Inamoto, Yoshihi ...
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Malone, Adriana ...
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DeFilipp, Zachar ...
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Margossian, Stev ...
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Warwick, Anne B.
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Jaglowski, Saman ...
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Beitinjaneh, Ame ...
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Fung, Henry
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Kasow, Kimberly ...
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Marks, David I.
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Reynolds, Jana
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Stockerl-Goldste ...
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Wirk, Baldeep
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Wood, William A.
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Hamadani, Mehdi
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Satwani, Prakash
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