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Nanodelivery of Cer...
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Requejo, C.Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Vizcaya, Spain.
(författare)
Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson's Disease
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2017-08-24
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Humana Press,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-346901
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-346901URI
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https://doi.org/10.1007/s12035-017-0741-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Rearing in enriched environment (EE) improves the recuperation in animal models of Parkinson's disease (PD). Administration of TiO2-nanowired cerebrolysin (CBL) could represent an additional strategy to protect or repair the nigrostriatal system. This study aims to explore morphofunctional and biochemical changes in a preclinical stage of PD testing the synergistic efficiency of combining both strategies, housing in EE, and nanodelivery of CBL. Sprague-Dawley male rats receiving intrastriatally 6-hydroxydopamine after a short evolution time were segregated into CBL group (rats receiving nanowired CBL), EE group (rats housed in EE), CBL + EE group (rats housed in EE and receiving nanowired CBL), and control group (rats without additional treatment). Prodromic stage and treatment effects were characterized by the presence of motor symptoms (amphetamine-induced rotational behavior test). Tyrosine hydroxylase (TH) immunohistochemistry and Western blot (p-Akt/Akt and p-ERK/ERK 1/2 as survival markers and caspase-3 as apoptotic marker) were performed in striatum and SN. A decrease in motor symptoms was shown by rats receiving CBL. EE monitoring cages revealed that rats from CBL + EE group showed more significant number of laps in the wheel than EE group. In SN, CBL + EE group also presented the highest neuronal density. Moreover, p-Akt/Akt and p-ERK/ERK 1/2 ratio was significant higher and caspase-3 expression was lower in CBL + EE group. In conclusion, the combination of CBL and EE provided evidence of neuoprotective-neurorestorative mechanisms by which this combined strategy promoted morphofunctional improvement by activation of survival pathways after dopamine depletion in a preclinical model of PD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ruiz-Ortega, J. A.Univ Basque Country UPV EHU, Dept Pharmacol, Leioa, Vizcaya, Spain.
(författare)
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Cepeda, H.Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Vizcaya, Spain.
(författare)
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Sharma, A.Uppsala Univ, Int Expt CNS Injury & Repair, Uppsala, Sweden.(Swepub:uu)arush975
(författare)
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Sharma, H.S.Uppsala universitet,Anestesiologi och intensivvård,Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Vizcaya, Spain.;Uppsala Univ, Int Expt CNS Injury & Repair, Uppsala, Sweden.(Swepub:uu)hssharma
(författare)
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Ozkizilcik, A.Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA.
(författare)
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Tian, R.Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA.;Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
(författare)
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Moessler, H.Ever Neuro Pharma, Drug Discovery & Develop, Oberburgau, Austria.
(författare)
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Ugedo, L.Univ Basque Country UPV EHU, Dept Pharmacol, Leioa, Vizcaya, Spain.
(författare)
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Lafuente, J. V.Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Vizcaya, Spain.;BioCruces Hlth Res Inst, Nanoneurosurg Grp, Baracaldo 48903, Vizcaya, Spain.;Univ Autonoma Chile, Fac Hlth Sci, Santiago, Chile.
(författare)
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Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Vizcaya, Spain.Univ Basque Country UPV EHU, Dept Pharmacol, Leioa, Vizcaya, Spain.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Neurobiology: Humana Press55:1, s. 286-2990893-76481559-1182
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Requejo, C.
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Ruiz-Ortega, J. ...
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Cepeda, H.
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Sharma, A.
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Sharma, H.S.
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Ozkizilcik, A.
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visa fler...
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Tian, R.
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Moessler, H.
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Ugedo, L.
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Lafuente, J. V.
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