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  • Feng, ChungangUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi (author)

Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • ELIFE SCIENCES PUBLICATIONS LTD,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-333409
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333409URI
  • https://doi.org/10.7554/eLife.23907DOI
  • https://res.slu.se/id/publ/92564URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (pi = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 x 10(-9) per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate the lowest among vertebrates analyzed to date - partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.

Subject headings and genre

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  • Pettersson, MatsUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University(Swepub:slu)49767 (author)
  • Lamichhaney, SangeetUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)sanla975 (author)
  • Rubin, Carl-JohanUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)carub021 (author)
  • Rafati, NimaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)nimra236 (author)
  • Casini, MicheleSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för akvatiska resurser,Department of Aquatic Resources,Swedish Univ Agr Sci, Dept Aquat Resources, Inst Marine Res, Lysekil, Sweden.(Swepub:slu)50882 (author)
  • Folkvord, ArildUniv Bergen, Dept Biol, Bergen, Norway.;Hjort Ctr Marine Ecosyst Dynam, Bergen, Norway.;Inst Marine Res, Bergen, Norway. (author)
  • Andersson, LeifSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.;Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University(Swepub:slu)48730 (author)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)
  • Sveriges lantbruksuniversitet

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