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Detection of autoan...
Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer
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- Djureinovic, Dijana (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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- Dodig-Crnkovic, Tea (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Solna, Sweden
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- Hellström, Cecilia (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Solna, Sweden
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- Holgersson, Georg (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Bergqvist, Michael (author)
- Department of Oncology, Gavle Hospital, Gavle, Sweden.
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- Mattsson, Johanna Sofia Margareta, 1985- (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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- Ponten, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén
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- Ståhle, Elisabeth (author)
- Uppsala universitet,Thoraxkirurgi,Uppsala kliniska forskningscentrum (UCR)
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Solna, Sweden
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- Micke, Patrick (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Lung Cancer. - : Elsevier BV. - 0169-5002 .- 1872-8332. ; 125, s. 157-163
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cancer testis antigens (CTAs) are defined as proteins that are specifically expressed in testis or placenta and their expression is frequently activated in cancer. Due to their ability to induce an immune response, CTAs may serve as suitable targets for immunotherapy. The aim of this study was to evaluate if there is reactivity against CTAs in the plasma of non-small cell lung cancer (NSCLC) patients through the detection of circulating antibodies. To comprehensively analyse auto-antibodies against CTAs the multiplexing capacities of suspension bead array technology was used. Bead arrays were created with 120 protein fragments, representing 112 CTAs. Reactivity profiles were measured in plasma samples from 133 NSCLC patients and 57 cases with benign lung diseases. Altogether reactivity against 69 antigens, representing 81 CTAs, was demonstrated in at least one of the analysed samples. Twenty-nine of the antigens (45 CTAs) demonstrated exclusive reactivity in NSCLC samples. Reactivity against CT47A genes, PAGE3, VCX, MAGEB1, LIN28B and C12orf54 were only found in NSCLC patients at a frequency of 1%-4%. The presence of autoantibodies towards these six antigens was confirmed in an independent group of 34 NSCLC patients.In conclusion, we identified autoantibodies against CTAs in the plasma of lung cancer patients. The reactivity pattern of autoantibodies was higher in cancer patients compared to the benign group, stable over time, but low in frequency of occurrence. The findings suggest that some CTAs are immunogenic and that these properties can be utilized as immune targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Keyword
- Lung cancer
- adenocarcinoma
- squamous cell cancer
- cancer immunity
- tumor markers
- MAGE
- PAGE
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Djureinovic, Dij ...
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Dodig-Crnkovic, ...
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Hellström, Cecil ...
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Holgersson, Geor ...
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Bergqvist, Micha ...
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Mattsson, Johann ...
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Ponten, Fredrik
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Ståhle, Elisabet ...
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Schwenk, Jochen ...
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Micke, Patrick
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
- Articles in the publication
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Lung Cancer
- By the university
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Uppsala University
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Royal Institute of Technology