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A biomarker-based r...
A biomarker-based risk score to predict death in patients with atrial fibrillation : the ABC (age, biomarkers, clinical history) death risk score
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- Hijazi, Ziad (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Oldgren, Jonas, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Lindbäck, Johan (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Alexander, John H. (författare)
- Duke Hlth, Duke Clin Res Inst, Durham, NC USA.
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- Connolly, Stuart J. (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Eikelboom, John W. (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Ezekowitz, Michael D. (författare)
- Thomas Jefferson Med Coll, Wynnewood, PA USA.;Ctr Heart, Wynnewood, PA USA.
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- Held, Claes, 1956- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Hylek, Elaine M. (författare)
- Boston Univ, Med Ctr, Boston, MA USA.
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- Lopes, Renato D. (författare)
- Duke Hlth, Duke Clin Res Inst, Durham, NC USA.
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- Yusuf, Salim (författare)
- Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Granger, Christopher B. (författare)
- Duke Hlth, Duke Clin Res Inst, Durham, NC USA.
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- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Klinisk kemi,Uppsala kliniska forskningscentrum (UCR)
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- 2017-10-21
- 2018
- Engelska.
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Ingår i: European Heart Journal. - : OXFORD UNIV PRESS. - 0195-668X .- 1522-9645. ; 39:6, s. 477-485
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: In atrial fibrillation (AF), mortality remains high despite effective anticoagulation. A model predicting the risk of death in these patients is currently not available. We developed and validated a risk score for death in anticoagulated patients with AF including both clinical information and biomarkers.Methods and results: The new risk score was developed and internally validated in 14 611 patients with AF randomized to apixaban vs. warfarin for a median of 1.9 years. External validation was performed in 8548 patients with AF randomized to dabigatran vs. warfarin for 2.0 years. Biomarker samples were obtained at study entry. Variables significantly contributing to the prediction of all-cause mortality were assessed by Cox-regression. Each variable obtained a weight proportional to the model coefficients. There were 1047 all-cause deaths in the derivation and 594 in the validation cohort. The most important predictors of death were N-terminal pro B-type natriuretic peptide, troponin-T, growth differentiation factor-15, age, and heart failure, and these were included in the ABC (Age, Biomarkers, Clinical history)-death risk score. The score was well-calibrated and yielded higher c-indices than a model based on all clinical variables in both the derivation (0.74 vs. 0.68) and validation cohorts (0.74 vs. 0.67). The reduction in mortality with apixaban was most pronounced in patients with a high ABC-death score.Conclusion: A new biomarker-based score for predicting risk of death in anticoagulated AF patients was developed, internally and externally validated, and well-calibrated in two large cohorts. The ABC-death risk score performed well and may contribute to overall risk assessment in AF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atrial fibrillation
- Biomarkers
- Mortality
- NOAC
- Oral anticoagulation
- Risk score
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hijazi, Ziad
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Oldgren, Jonas, ...
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Lindbäck, Johan
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Alexander, John ...
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Connolly, Stuart ...
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Eikelboom, John ...
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Ezekowitz, Micha ...
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Held, Claes, 195 ...
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Hylek, Elaine M.
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Lopes, Renato D.
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Yusuf, Salim
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Granger, Christo ...
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Siegbahn, Agneta ...
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Wallentin, Lars, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
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Uppsala universitet