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Prenatal exposure t...
Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
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- Gunnarsdottir, Johanna (författare)
- Uppsala universitet,Forskargrupper (Inst. för kvinnors och barns hälsa)
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- Cnattingius, Sven (författare)
- Karolinska Institutet
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- Lundgren, Maria (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden.
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- Ekholm Selling, Katarina, 1976- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Högberg, Ulf, 1949- (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Wikström, Anna-Karin, 1965- (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk obstetrik,Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.
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Uppsala universitet Forskargrupper (Inst för kvinnors och barns hälsa) (creator_code:org_t)
- 2018-02-13
- 2018
- Engelska.
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Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 13:2
- Relaterad länk:
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. Methods In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. Results Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant's breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3-1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1-0.7 cm). Conclusion Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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