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Search: (WFRF:(Paulo Paula)) pers:(Pandha Hardev) > (2015) > Prediction of indiv...

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  • Szulkin, RobertKarolinska Institutet (author)

Prediction of individual genetic risk to prostate cancer using a polygenic score.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-07-14
  • Wiley,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-349374
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349374URI
  • https://doi.org/10.1002/pros.23037DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131812275URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Pär Stattin, Institutionen för kirurgiska vetenskaper, urologi, Uppsala universitet är en av medarbetarna, collaborators. 
  • BACKGROUND: Polygenic risk scores comprising established susceptibility variants have shown to be informative classifiers for several complex diseases including prostate cancer. For prostate cancer it is unknown if inclusion of genetic markers that have so far not been associated with prostate cancer risk at a genome-wide significant level will improve disease prediction.METHODS: We built polygenic risk scores in a large training set comprising over 25,000 individuals. Initially 65 established prostate cancer susceptibility variants were selected. After LD pruning additional variants were prioritized based on their association with prostate cancer. Six-fold cross validation was performed to assess genetic risk scores and optimize the number of additional variants to be included. The final model was evaluated in an independent study population including 1,370 cases and 1,239 controls.RESULTS: The polygenic risk score with 65 established susceptibility variants provided an area under the curve (AUC) of 0.67. Adding an additional 68 novel variants significantly increased the AUC to 0.68 (P = 0.0012) and the net reclassification index with 0.21 (P = 8.5E-08). All novel variants were located in genomic regions established as associated with prostate cancer risk.CONCLUSIONS: Inclusion of additional genetic variants from established prostate cancer susceptibility regions improves disease prediction.

Subject headings and genre

  • polygenic risk score
  • prostate cancer
  • risk prediction

Added entries (persons, corporate bodies, meetings, titles ...)

  • Whitington, ThomasKarolinska Institutet (author)
  • Eklund, MartinKarolinska Institutet (author)
  • Aly, MarkusKarolinska Institutet (author)
  • Eeles, Rosalind A (author)
  • Easton, Douglas (author)
  • Kote-Jarai, Z Sofia (author)
  • Amin Al Olama, Ali (author)
  • Benlloch, Sara (author)
  • Muir, Kenneth (author)
  • Giles, Graham G (author)
  • Southey, Melissa C (author)
  • Fitzgerald, Liesel M (author)
  • Henderson, Brian E (author)
  • Schumacher, Fredrick (author)
  • Haiman, Christopher A (author)
  • Schleutker, Johanna (author)
  • Wahlfors, Tiina (author)
  • Tammela, Teuvo L J (author)
  • Nordestgaard, Børge G (author)
  • Key, Tim J (author)
  • Travis, Ruth C (author)
  • Neal, David E (author)
  • Donovan, Jenny L (author)
  • Hamdy, Freddie C (author)
  • Pharoah, Paul (author)
  • Pashayan, Nora (author)
  • Khaw, Kay-Tee (author)
  • Stanford, Janet L (author)
  • Thibodeau, Stephen N (author)
  • McDonnell, Shannon K (author)
  • Schaid, Daniel J (author)
  • Maier, Christiane (author)
  • Vogel, Walther (author)
  • Luedeke, Manuel (author)
  • Herkommer, Kathleen (author)
  • Kibel, Adam S (author)
  • Cybulski, Cezary (author)
  • Lubiński, Jan (author)
  • Kluźniak, Wojciech (author)
  • Cannon-Albright, Lisa (author)
  • Brenner, Hermann (author)
  • Butterbach, Katja (author)
  • Stegmaier, Christa (author)
  • Park, Jong Y (author)
  • Sellers, Thomas (author)
  • Lin, Hui-Yi (author)
  • Lim, Hui-Yi (author)
  • Slavov, Chavdar (author)
  • Kaneva, Radka (author)
  • Mitev, Vanio (author)
  • Batra, Jyotsna (author)
  • Clements, Judith A (author)
  • Spurdle, Amanda (author)
  • Teixeira, Manuel R (author)
  • Paulo, Paula (author)
  • Maia, Sofia (author)
  • Pandha, Hardev (author)
  • Michael, Agnieszka (author)
  • Kierzek, Andrzej (author)
  • Gronberg, HenrikKarolinska Institutet (author)
  • Wiklund, FredrikKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:The Prostate: Wiley75:13, s. 1467-740270-41371097-0045

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