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Role of a single no...
Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella
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- Hammarlöf, Disa L. (författare)
- Uppsala universitet,Mikrobiologi,Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
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- Kroger, Carsten (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.;Trinity Coll Dublin, Sch Genet & Microbiol, Moyne Inst Prevent Med, Dept Microbiol, Dublin 2, Ireland.
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- Owen, Sian V. (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.
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- Canals, Rocio (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.
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- Lacharme-Lora, Lizeth (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.
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- Wenner, Nicolas (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.
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- Schager, Anna E. (författare)
- Univ Birmingham, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England.
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- Wells, Timothy J. (författare)
- Univ Birmingham, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England.
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- Henderson, Ian R. (författare)
- Univ Birmingham, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England.
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- Wigley, Paul (författare)
- Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7ZB, Merseyside, England.
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- Hokamp, Karsten (författare)
- Univ Dublin, Trinity Coll Dublin, Sch Genet & Microbiol, Dept Genet,Smurfit Inst Genet, Dublin 2, Ireland.
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- Feasey, Nicholas A. (författare)
- Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England.;Univ Malawi, Coll Med, Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre 3, Malawi.
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- Gordon, Melita A. (författare)
- Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7ZB, Merseyside, England.;Univ Malawi, Coll Med, Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre 3, Malawi.
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- Hinton, Jay C. D. (författare)
- Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England.
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(creator_code:org_t)
- 2018-02-27
- 2018
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:11, s. E2614-E2623
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Abstract
Ämnesord
Stäng
- Salmonella enterica serovar Typhimurium ST313 is a relatively newly emerged sequence type that is causing a devastating epidemic of bloodstream infections across sub-Saharan Africa. Analysis of hundreds of Salmonella genomes has revealed that ST313 is closely related to the ST19 group of S. Typhimurium that cause gastroenteritis across the world. The core genomes of ST313 and ST19 vary by only similar to 1,000 SNPs. We hypothesized that the phenotypic differences that distinguish African Salmonella from ST19 are caused by certain SNPs that directly modulate the transcription of virulence genes. Here we identified 3,597 transcriptional start sites of the ST313 strain D23580, and searched for a gene-expression signature linked to pathogenesis of Salmonella. We identified a SNP in the promoter of the pgtE gene that caused high expression of the PgtE virulence factor in African S. Typhimurium, increased the degradation of the factor B component of human complement, contributed to serum resistance, and modulated virulence in the chicken infection model. We propose that high levels of PgtE expression by African S. Typhimurium ST313 promote bacterial survival and dissemination during human infection. Our finding of a functional role for an extragenic SNP shows that approaches used to deduce the evolution of virulence in bacterial pathogens should include a focus on noncoding regions of the genome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Salmonella
- noncoding genome
- transcriptomics
- evolution of virulence
- host adaptation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hammarlöf, Disa ...
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Kroger, Carsten
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Owen, Sian V.
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Canals, Rocio
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Lacharme-Lora, L ...
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Wenner, Nicolas
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visa fler...
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Schager, Anna E.
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Wells, Timothy J ...
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Henderson, Ian R ...
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Wigley, Paul
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Hokamp, Karsten
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Feasey, Nicholas ...
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Gordon, Melita A ...
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Hinton, Jay C. D ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Proceedings of t ...
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Uppsala universitet