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  • Wannan, Cassandra M.J.University of Melbourne,Orygen - National Centre for Excellence in Youth Mental Health (author)

Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:358cd91c-47f5-42d5-b1fb-a11d04cc1243
  • https://lup.lub.lu.se/record/358cd91c-47f5-42d5-b1fb-a11d04cc1243URI
  • https://doi.org/10.1016/j.psychres.2024.116073DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Eratne, DhamidhuUniversity of Melbourne,Royal Melbourne Hospital (author)
  • Santillo, Alexander F.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)med-ast (author)
  • Malpas, CharlesUniversity of Melbourne (author)
  • Cilia, BrandonRoyal Melbourne Hospital (author)
  • Dean, Olivia M.The Florey Institute of Neuroscience and Mental Health,Deakin University (author)
  • Walker, AdamDeakin University (author)
  • Berk, MichaelDeakin University (author)
  • Bousman, ChadUniversity of Melbourne,University of Calgary (author)
  • Everall, IanKing's College London (author)
  • Velakoulis, DennisUniversity of Melbourne,Royal Melbourne Hospital (author)
  • Pantelis, ChristosUniversity of Melbourne,Monash Institute of Pharmaceutical Sciences (author)
  • University of MelbourneOrygen - National Centre for Excellence in Youth Mental Health (creator_code:org_t)
  • MiND Study Group

Related titles

  • In:Psychiatry Research3390165-1781

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