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Neoadjuvant Therapy...
Neoadjuvant Therapy in Rectal Cancer Patients With Clinical Stage II to III Across European Countries : Variations and Outcomes
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- Babaei, Masoud (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, INF 581, Heidelberg, Germany.
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- Jansen, Lina (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, INF 581, Heidelberg, Germany.
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- Balavarca, Yesilda (author)
- German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis, Heidelberg, Germany.
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- Sjovall, Annika (author)
- Karolinska Institutet
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- Bos, Amanda (author)
- Comprehens Canc Org Netherlands, Utrecht, Netherlands.;Erasmus MC Univ Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.
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- van de Velde, Tony (author)
- Netherlands Canc Inst, Biometr Dept, Amsterdam, Netherlands.
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- Moreau, Michel (author)
- Inst Jules Bordet, Datactr, Brussels, Belgium.
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- Liberale, Gabriel (author)
- Inst Jules Bordet, Datactr, Brussels, Belgium.
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- Goncalves, Ana Filipa (author)
- Portuguese Oncol Inst Porto, Porto, Portugal.
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- Bento, Maria Jose (author)
- Portuguese Oncol Inst Porto, Porto, Portugal.
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- Ulrich, Cornelia M. (author)
- German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany.
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- Schrotz-King, Petra (author)
- German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis, Heidelberg, Germany.
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- Lemmens, Valery (author)
- Comprehens Canc Org Netherlands, Utrecht, Netherlands.;Erasmus MC Univ Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Brenner, Hermann (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, INF 581, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany.
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German Canc Res Ctr, Div Clin Epidemiol & Aging Res, INF 581, Heidelberg, Germany German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis, Heidelberg, Germany. (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Clinical colorectal cancer. - : Elsevier BV. - 1533-0028 .- 1938-0674. ; 17:1, s. E129-E142
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- This study is the largest observational study on neoadjuvant therapy in patients with stage II & III rectal cancer by including high-quality data from large population-based and clinical cancer registries. We observed large variations in administration of neoadjuvant chemo(radio) therapy across European countries. Our results support major survival advantages of patients treated with neoadjuvant radiotherapy. Background: Neoadjuvant therapy improves survival of patients with clinical stage II and III rectal cancer in clinical trials. In this study, we investigated the administration of neoadjuvant radiotherapy (neo-RT) and neoadjuvant chemoradiotherapy (neo-CRT) and its association with survival in resected patients in 2 European countries (The Netherlands and Sweden) and at 3 specialist centers. Materials and Methods: Administration of neoadjuvant treatment (all registries) and overall survival after surgery in The Netherlands and Sweden were assessed. Hazard ratios (HRs) were obtained using Cox regression adjusted for potential confounders. Results: A total of 16,095 rectal cancer patients with clinical stage II and III were eligible for analyses. Large variations in administration of neo-RT and neo-CRT were observed. Elderly patients less often received neo-RT and neo-CRT. Patients with stage III disease received neo-CRT more frequently than neo-RT. Administration of neo-RT versus surgery without neoadjuvant treatment was significantly associated with improved survival in The Netherlands (HR, 0.62; 95% confidence interval [CI], 0.53-0.73) as well as in Sweden (HR, 0.79; 95% CI, 0.69-0.90). Administration of neo-CRT was associated with enhanced survival in The Netherlands (HR, 0.62; 95% CI, 0.50-0.78) but not in Sweden (HR, 0.97; 95% CI, 0.80-1.18). The mortality of patients treated with neo-CRT compared with neo-RT showed inconsistent results in population-based centers. Conclusions: Our results support an association of neo-RT with enhanced survival among stage II and III rectal cancer patients. Comparing neo-CRT with neo-RT, larger variations and inconsistent results with respect to survival were observed across centers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Long-term outcomes
- Neoadjuvant therapy
- Rectal cancer
- Survival
- Variations
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Babaei, Masoud
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Jansen, Lina
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Balavarca, Yesil ...
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Sjovall, Annika
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Bos, Amanda
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van de Velde, To ...
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show more...
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Moreau, Michel
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Liberale, Gabrie ...
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Goncalves, Ana F ...
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Bento, Maria Jos ...
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Ulrich, Cornelia ...
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Schrotz-King, Pe ...
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Lemmens, Valery
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Glimelius, Bengt
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Brenner, Hermann
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Clinical colorec ...
- By the university
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Uppsala University
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Karolinska Institutet