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Intravenous versus ...
Intravenous versus oral etoposide : efficacy and correlation to clinical outcome in patients with high-grade metastatic gastroenteropancreatic neuroendocrine neoplasms (WHO G3)
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- Ali, Abir Salwa (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Grönberg, Malin, 1980- (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Langer, Seppo W. (författare)
- Univ Copenhagen, Rigshosp, Fac Hlth Sci, Dept Surg C, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Fac Hlth Sci, Dept Endocrinol PE, Copenhagen, Denmark.;Rigshosp, Copenhagen Univ Hosp, Dept Oncol, Copenhagen, Denmark.
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- Ladekarl, Morten (författare)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
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- Hjortland, Geir Olav (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Vestermark, Lene Weber (författare)
- Odense Univ Hosp, Dept Oncol, Odense, Denmark.
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- Österlund, Pia (författare)
- Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Welin, Staffan (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Gronbaek, Henning (författare)
- Aarhus Univ Hosp, Dept Hepatol, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Gastroenterol, Aarhus, Denmark.
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- Knigge, Ulrich (författare)
- Univ Copenhagen, Rigshosp, Fac Hlth Sci, Dept Surg C, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Fac Hlth Sci, Dept Endocrinol PE, Copenhagen, Denmark.;Rigshosp, Copenhagen Univ Hosp, Dept Oncol, Copenhagen, Denmark.
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- Sorbye, Halfdan (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway.
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- Janson, Eva Tiensuu (författare)
- Uppsala universitet,Onkologisk endokrinologi
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(creator_code:org_t)
- 2018-03-06
- 2018
- Engelska.
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Ingår i: Medical Oncology. - : Springer. - 1357-0560 .- 1559-131X. ; 35:4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs, G3) are aggressive cancers of the digestive system with poor prognosis and survival. Platinum-based chemotherapy (cisplatin/carboplatin + etoposide) is considered the first-line palliative treatment. Etoposide is frequently administered intravenously; however, oral etoposide may be used as an alternative. Concerns for oral etoposide include decreased bioavailability, inter-and intra-patient variability and patient compliance. We aimed to evaluate possible differences in progression-free survival (PFS) and overall survival (OS) in patients treated with oral etoposide compared to etoposide given as infusion. Patients (n = 236) from the Nordic NEC study were divided into three groups receiving etoposide as a long infusion (24 h, n = 170), short infusion (= 5 h, n = 33) or oral etoposide (n = 33) according to hospital tradition. PFS and OS were analyzed with Kaplan-Meier (log-rank), cox proportional hazard ratios and confidence intervals. No statistical differences were observed in PFS or OS when comparing patients receiving long infusion (median PFS 3.8 months, median OS 14.5 months), short infusion (PFS 5.6 months, OS 11.0 months) or oral etoposide (PFS 5.4 months, OS 11.3 months). We observed equal efficacy for the three administration routes suggesting oral etoposide may be safe and efficient in treating high-grade GEP-NEN, G3 patients scheduled for cisplatin/carboplatin + etoposide therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Chemotherapy
- Intravenous
- Oral
- Etoposide
- Neuroendocrine neoplasms
- WHO G3
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Ali, Abir Salwa
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Grönberg, Malin, ...
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Langer, Seppo W.
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Ladekarl, Morten
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Hjortland, Geir ...
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Vestermark, Lene ...
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Österlund, Pia
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Welin, Staffan
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Gronbaek, Hennin ...
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Knigge, Ulrich
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Sorbye, Halfdan
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Janson, Eva Tien ...
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Medical Oncology
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