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Amino acid tracers ...
Amino acid tracers in PET imaging of diffuse low-grade gliomas : a systematic review of preoperative applications
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- Näslund, Olivia (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Smits, Anja (författare)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Neurologi,Sahlgrens Acad, Inst Physiol & Neurosci, Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Förander, Petter (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; Karolinska Inst, Dept Med, Stockholm, Sweden; Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden
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- Laesser, Mats, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Bartek, Jiri, Jr (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; Karolinska Inst, Dept Med, Stockholm, Sweden; St Olavs Hosp, Dept Neurosurg, Trondheim, Norway; Rigshosp, Dept Neurosurg, Copenhagen Univ Hosp, Copenhagen, Denmark
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- Gempt, Jens (författare)
- Tech Univ Munich, Dept Neurosurg, Klinikum Rechts Isar, Munich, Germany
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- Liljegren, Ann (författare)
- Sahlgrens Univ Hosp, Dept Radiol, Gothenburg, Sweden
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- Daxberg, Eva-Lotte (författare)
- Sahlgrens Univ Hosp, Dept Radiol, Gothenburg, Sweden
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- Jakola, Asgeir Store (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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(creator_code:org_t)
- 2018-05-24
- 2018
- Engelska.
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Ingår i: Acta Neurochirurgica. - : Springer Nature. - 0001-6268 .- 0942-0940. ; 160:7, s. 1451-1460
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Positron emission tomography (PET) imaging using amino acid tracers has in recent years become widely used in the diagnosis and prediction of disease course in diffuse low-grade gliomas (LGG). However, implications of preoperative PET for treatment and prognosis in this patient group have not been systematically studied. The aim of this systematic review was to evaluate the preoperative diagnostic and prognostic value of amino acid PET in suspected diffuse LGG. Medline, Cochrane Library, and Embase databases were systematically searched using keywords "PET," "low-grade glioma," and "amino acids tracers" with their respective synonyms. Out of 2137 eligible studies, 28 met the inclusion criteria. Increased amino acid uptake (lesion/brain) was consistently reported among included studies; in 25-92% of subsequently histopathology-verified LGG, in 83-100% of histopathology-verified HGG, and also in some non-neoplastic lesions. No consistent results were found in studies reporting hot spot areas on PET in MRI-suspected LGG. Thus, the diagnostic value of amino acid PET imaging in suspected LGG has proven difficult to interpret, showing clear overlap and inconsistencies among reported results. Similarly, the results regarding the prognostic value of PET in suspected LGG and the correlation between uptake ratios and the molecular tumor status of LGG were conflicting. This systematic review illustrates the difficulties with prognostic studies presenting data on group-level without adjustment for established clinical prognostic factors, leading to a loss of additional prognostic information. We conclude that the prognostic value of PET is limited to analysis of histological subgroups of LGG and is probably strongest when using kinetic analysis of dynamic FET uptake parameters.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Amino acid
- Biopsy
- Glioma
- PET
- Prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Näslund, Olivia
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Smits, Anja
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Förander, Petter
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Laesser, Mats, 1 ...
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Bartek, Jiri, Jr
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Gempt, Jens
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Liljegren, Ann
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Daxberg, Eva-Lot ...
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Jakola, Asgeir S ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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MEDICIN OCH HÄLS ...
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Acta Neurochirur ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Göteborgs universitet