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Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS : a secondary analysis of PRoVENT

Simonis, Fabienne D. (författare)
Acad Med Ctr, Dept Intens Care, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands;Acad Med Ctr, LEICA, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
Barbas, Carmen S. V. (författare)
Hosp Israelita Albert Einstein, Dept Intens Care Med, Sao Paulo, Brazil;Univ Sao Paulo, Fac Med, Dept Pulmonol, Sao Paulo, Brazil
Artigas-Raventos, Antonio (författare)
Corporacio Sanitaria Univ Parc Tauli, Hosp Sabadell, Dept Intens Care Med, Sabadell, Spain;Corporacio Sanitaria Univ Parc Tauli, Hosp Sabadell, CIBER Enfermedades Resp, Sabadell, Spain
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Canet, Jaume (författare)
Univ Hosp Germans Trias I Pujol, Dept Anesthesiol, Barcelona, Spain
Determann, Rogier M. (författare)
Westfriesgasthuis, Dept Crit Care, Hoorn, Netherlands
Anstey, James (författare)
St Vincents Hosp, Dept Intens Care, Melbourne, Vic, Australia
Hedenstierna, Göran, 1941- (författare)
Uppsala universitet,Klinisk fysiologi
Hemmes, Sabrine N. T. (författare)
Acad Med Ctr, Dept Anesthesiol, Amsterdam, Netherlands
Hermans, Greet (författare)
Univ Hosp Leuven, Div Gen Internal Med, Med Intens Care Unit, Louvain, Belgium;Katholieke Univ Leuven, Dept Cellular & Mol Med, Lab Intens Care Med, Louvain, Belgium
Hiesmayr, Michael (författare)
Med Univ Vienna, Div Cardiac Thorac & Vasc Anesthesia & Intens Car, Vienna, Austria
Hollmann, Markus W. (författare)
Acad Med Ctr, Dept Anesthesiol, Amsterdam, Netherlands
Jaber, Samir (författare)
St Eloi Univ Hosp, Dept Crit Care Med & Anesthesiol SAR B, Montpellier, France
Martin-Loeches, Ignacio (författare)
St Jamess Univ, Hosp Dublin, HRB Clin Res, Welcome Trust,MICRO,Trinity Ctr Hlth Sci,Dept Cli, Dublin, Ireland;ICVB, Dublin, Ireland
Mills, Gary H. (författare)
Sheffield Teaching Hosp, Dept Anaesthesia & Crit Care Med, Sheffield, S Yorkshire, England
Pearse, Rupert M. (författare)
Queen Mary Univ London, Barts & London Sch Med & Dent, London, England
Putensen, Christian (författare)
Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany
Schmid, Werner (författare)
Med Univ Vienna, Div Cardiac Thorac & Vasc Anesthesia & Intens Car, Vienna, Austria
Severgnini, Paolo (författare)
Insubria Univ, Dept Biotechnol & Sci Life, Varese, Italy
Smith, Roger (författare)
St Vincents Hosp, Dept Intens Care, Melbourne, Vic, Australia
Treschan, Tanja A. (författare)
Med Univ Vienna, Div Cardiac Thorac & Vasc Anesthesia & Intens Car, Vienna, Austria;Dusseldorf Univ Hosp, Dept Anaesthesiol, Dusseldorf, Germany
Tschernko, Edda M. (författare)
Melo, Marcos F. Vidal (författare)
Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA
Wrigge, Hermann (författare)
Univ Leipzig, Dept Anesthesiol & Intens Care Med, Leipzig, Germany
de Abreu, Marcelo Gama (författare)
Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Med, Pulm Engn Grp, Dresden, Germany;Tech Univ Dresden, Dept Anesthesiol & Intens Care Med, Pulm Engn Grp, Dresden, Germany
Pelosi, Paolo (författare)
Univ Genoa, IRCCS Oncol, Osped Policlin Oncol, Dept Surg Sci & Integrated Diagnost, Genoa, Italy
Schultz, Marcus J. (författare)
Acad Med Ctr, Dept Intens Care, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands;Acad Med Ctr, LEICA, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands;Mahidol Univ, MORU, Bangkok, Thailand
Serpa Neto, Ary (författare)
Acad Med Ctr, Dept Intens Care, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands;Acad Med Ctr, LEICA, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands;Hosp Israelita Albert Einstein, Dept Intens Care Med, Sao Paulo, Brazil
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 (creator_code:org_t)
2018-03-21
2018
Engelska.
Ingår i: Annals of Intensive Care. - : Springer Berlin/Heidelberg. - 2110-5820. ; 8
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://annalsofinte...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The majority of critically ill patients do not suffer from acute respiratory distress syndrome (ARDS). To improve the treatment of these patients, we aimed to identify potentially modifiable factors associated with outcome of these patients. Methods: The PRoVENT was an international, multicenter, prospective cohort study of consecutive patients under invasive mechanical ventilatory support. A predefined secondary analysis was to examine factors associated with mortality. The primary endpoint was all-cause in-hospital mortality. Results: 935 Patients were included. In-hospital mortality was 21%. Compared to patients who died, patients who survived had a lower risk of ARDS according to the 'Lung Injury Prediction Score' and received lower maximum airway pressure (P-max), driving pressure (Delta P), positive end-expiratory pressure, and FiO(2) levels. Tidal volume size was similar between the groups. Higher P-max was a potentially modifiable ventilatory variable associated with in-hospital mortality in multivariable analyses. Delta P was not independently associated with in-hospital mortality, but reliable values for Delta P were available for 343 patients only. Non-modifiable factors associated with in-hospital mortality were older age, presence of immunosuppression, higher non-pulmonary sequential organ failure assessment scores, lower pulse oximetry readings, higher heart rates, and functional dependence. Conclusions: Higher P-max was independently associated with higher in-hospital mortality in mechanically ventilated critically ill patients under mechanical ventilatory support for reasons other than ARDS.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Mechanical ventilation
Outcome
Mortality
Ventilator settings

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