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Search: WFRF:(Pani Roberto) > The MINDVIEW project :

  • Benlloch, Jose M.Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain (author)

The MINDVIEW project : First results

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2020-01-01
  • Cambridge University Press (CUP),2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-353215
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353215URI
  • https://doi.org/10.1016/j.eurpsy.2018.01.002DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138101156URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gonzalez, Antonio J.Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain (author)
  • Pani, RobertoSapienza Univ Rome, Dept Mol Med, Rome, Italy (author)
  • Preziosi, EnricoSapienza Univ Rome, Dept Mol Med, Rome, Italy (author)
  • Jackson, CarlSensL Technol, Cork, Ireland (author)
  • Murphy, JohnSensL Technol, Cork, Ireland (author)
  • Barbera, JulioOncovision, Valencia, Spain (author)
  • Correcher, CarlosOncovision, Valencia, Spain (author)
  • Aussenhofer, SebastianNORAS MRI Prod GmbH, Hochberg, Germany (author)
  • Gareis, DanielNORAS MRI Prod GmbH, Hochberg, Germany (author)
  • Visvikis, DimitrisUniv Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France (author)
  • Bert, JulienUniv Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France (author)
  • Langstrom, BengtBENCAR, Uppsala, Sweden (author)
  • Farde, LarsKarolinska Institutet (author)
  • Toth, MiklosKarolinska Institutet (author)
  • Haggkvist, JennyKarolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm, Sweden (author)
  • Caixeta, Fabio ViegasUppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)fabvi863 (author)
  • Kullander, Klas,1966-Uppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)klkul255 (author)
  • Somlai-Schweiger, IanTech Univ Munich, Dept Nucl Med, Munich, Germany (author)
  • Schwaiger, MarkusTech Univ Munich, Dept Nucl Med, Munich, Germany (author)
  • Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, SpainSapienza Univ Rome, Dept Mol Med, Rome, Italy (creator_code:org_t)

Related titles

  • In:European psychiatry: Cambridge University Press (CUP)50, s. 21-270924-93381778-3585

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