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Prostaglandin E-2 s...
Prostaglandin E-2 suppresses human group 2 innate lymphoid cell function
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- Maric, Jovana (author)
- Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria;Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden
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- Ravindran, Avinash (author)
- Karolinska Inst, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden
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- Mazzurana, Luca (author)
- Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden
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- Björklund, Åsa K. (author)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sweden
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- Van Acker, Aline (author)
- Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden
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- Rao, Anna (author)
- Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden
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- Friberg, Danielle (author)
- Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden;Karolinska Inst, CLINTEC, Stockholm, Sweden
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- Dahlen, Sven-Erik (author)
- Karolinska Inst, Inst Environm Med, Expt Asthma & Allergy Res, Stockholm, Sweden
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- Heinemann, Akos (author)
- Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria
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- Konya, Viktoria (author)
- Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria;Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden
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- Mjösberg, Jenny (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Karolinska Inst, Sweden
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(creator_code:org_t)
- MOSBY-ELSEVIER, 2018
- 2018
- English.
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In: Journal of Allergy and Clinical Immunology. - : MOSBY-ELSEVIER. - 0091-6749 .- 1097-6825. ; 141:5, s. 1761-1773.e6
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Abstract
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- Background: Group 2 innate lymphoid cells (ILC2s) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. Prostaglandin (PG) E-2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation.Objective: We set out to investigate how PGE(2) regulates human ILC2 function.Methods: The effects of PGE(2) on human ILC2 proliferation and intracellular cytokine and transcription factor expression were assessed by means of flow cytometry. Cytokine production was measured by using ELISA, and real-time quantitative PCR was performed to detect PGE(2) receptor expression.Results: PGE(2) inhibited GATA-3 expression, as well as production of the type 2 cytokines IL-5 and IL-13, from human tonsillar and blood ILC2s in response to stimulation with a combination of IL-25, IL-33, thymic stromal lymphopoietin, and IL-2. Furthermore, PGE(2) downregulated the expression of IL-2 receptor alpha (CD25). In line with this observation, PGE(2) decreased ILC2 proliferation. These effects were mediated by the combined action of E-type prostanoid receptor (EP) 2 and EP4 receptors, which were specifically expressed on ILC2s.Conclusion: Our findings reveal that PGE(2) limits ILC2 activation and propose that selective EP2 and EP4 receptor agonists might serve as a promising therapeutic approach in treating allergic diseases by suppressing ILC2 function.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- ILC2
- allergy
- prostaglandin E-2
- E-type prostanoid receptor 2
- E-type prostanoid receptor 4
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Maric, Jovana
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Ravindran, Avina ...
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Mazzurana, Luca
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Björklund, Åsa K ...
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Van Acker, Aline
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Rao, Anna
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Friberg, Daniell ...
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Dahlen, Sven-Eri ...
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Heinemann, Akos
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Konya, Viktoria
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Mjösberg, Jenny
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Journal of Aller ...
- By the university
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Uppsala University
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Linköping University