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  • Pyykko, Okko T.Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)

Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • ELSEVIER SCIENCE INC,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-356808
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356808URI
  • https://doi.org/10.1016/j.wneu.2018.01.107DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECT: To investigate the incidence, comorbidities, mortality, and causes of death in idiopathic normal pressure hydrocephalus (iNPH). METHODS: A cohort of 536 patients with possible NPH from a defined population with a median follow-up time of 5.1 years, (range 0.04-19.9 years) was included in the study. Patients were evaluated by brain imaging and intraventricular pressure monitoring, with a brain biopsy specimen immunostained against amyloid-beta and hyper-phosphorylated tau. Hospital records were reviewed for vascular diseases and type 2 diabetes mellitus (T2DM). Death certificates and yearly population of the catchment area were obtained from national registries. RESULTS: A total of 283 patients had a clinical diagnosis of iNPH, leading to a median annual incidence of 1.58 iNPH patients per 100,000 inhabitants (range, 0.8-4.5). Alzeimer disease-related brain biopsy findings were less frequent in iNPH patients than in non-iNPH patients (P < 0.05). An overrepresentation of hypertension (52% vs. 33%, P < 0.001) and T2DM (23% vs. 13%, P = 0.002) was noted in iNPH patients. Age (hazard ratio [HR] 1.04/year, 95% confidence interval [CI] 1.03-1.06, P< 0.001) and T2DM (HR 1.63, 95% CI 1.23-2.16, P < 0.001) increased the risk of death in the iNPH patients and in the total population. iNPH was associated with decreased risk of death (HR 0.63, 95% CI 0.50-0.78, P < 0.001). The most frequent causes of death were cardiovascular and cerebrovascular disease. Dementia as a cause of death was more common in non-iNPH patients (27% vs. 10%, P < 0.001). CONCLUSIONS: Hypertension and T2DM are common in iNPH and the latter causes excess mortality in the affected patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nerg, OssiKuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland (författare)
  • Niskasaari, Hanna-MariKuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)
  • Niskasaari, TimoKuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)
  • Koivisto, Anne M.Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland (författare)
  • Hiltunen, MikkoUniv Eastern Finland, Inst Biomed, Dept Neurol, Kuopio Univ Hosp, Kuopio, Finland (författare)
  • Pihlajamaki, JussiUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Dept Clin Nutr, Kuopio, Finland;Kuopio Univ Hosp, Clin Nutr & Obes Ctr, Kuopio, Finland (författare)
  • Rauramaa, TuomasKuopio Univ Hosp, Dept Pathol, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Pathol, Kuopio, Finland (författare)
  • Kojoukhova, MariaKuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)
  • Alafuzoff, IrinaUppsala universitet,Klinisk och experimentell patologi,Irina Alafuzoff(Swepub:uu)irial548 (författare)
  • Soininen, HilkkaKuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland (författare)
  • Jaaskelainen, Juha E.Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)
  • Leinonen, VilleKuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland (författare)
  • Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, FinlandKuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:World Neurosurgery: ELSEVIER SCIENCE INC112, s. E624-E6311878-87501878-8769

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