Ten Year Mortality in Different Peripheral Arterial Disease Stages: A Population Based Observational Study on Outcome

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Sartipy, FredrikKarolinska Institutet (author)

Ten Year Mortality in Different Peripheral Arterial Disease Stages : A Population Based Observational Study on Outcome

Article/chapterEnglish2018

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W B SAUNDERS CO LTD,2018
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LIBRIS-ID:oai:DiVA.org:uu-356811
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356811URI
https://doi.org/10.1016/j.ejvs.2018.01.019DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148262URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:138288348URI

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Language:English
Summary in:English

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Funding Agencies|Swedish Heart-Lung Foundation; Varmlands County Research Council; Sanofi-Aventis
Objective: The aim was to determine long-term mortality rates and the underlying cause of death for subjects with different peripheral arterial disease (PAD) stages in a population based setting. Methods: A randomly selected population sample of 5080 subjects was enrolled in the study in 2004-2005. Participants completed health state questionnaires and underwent ankle brachial index (ABI) measurements for classification into PAD severity stages and reference subjects. A follow-up was conducted by the end of 2015 using data from Swedish governmental national registers for cause of death, which was then compared with PAD stage determined at baseline in 2005. Results: The 10 year all cause mortality was 27% for reference cases, 56% for asymptomatic PAD (APAD), 63% for intermittent claudication (IC), and 75% for severe limb ischaemia (SLI). Among all PAD subjects, cardiovascular (CV) causes were the most common main cause of death (45%) and a CV event was present as either the main or one of the three most common contributing causes of death in 64% of the cases. The age adjusted hazard ratios for a main cause of death by a CV event were 1.9 (95% CI 1.5-2.3) for APAD, 2.6 (95% CI 2.1-3.4) for IC, and 3.5 (95% CI 2.3-5.2) for SLI. Conclusion: PAD subjects, including the APAD subjects, are still at high risk of CV death. The mortality risks are more than doubled in symptomatic PAD patients compared with reference subjects and increase by severity of PAD stage. Awareness and improved risk reduction management of PAD are still warranted.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Peripheral arterial disease
Mortality
Cardiovascular death

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Sigvant, BirgittaUppsala universitet,Kärlkirurgi,Uppsala Univ, Sweden(Swepub:uu)birsi511 (author)
Lundin, FredrikCty Council Varmland, Clin Res Ctr, Karlstad, Sweden (author)
Wahlberg, EricLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland(Swepub:liu)eriwa73 (author)
Karolinska InstitutetKärlkirurgi (creator_code:org_t)

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In:European Journal of Vascular and Endovascular Surgery: W B SAUNDERS CO LTD55:4, s. 529-5361078-58841532-2165

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By the author/editor: Sartipy, Fredrik; Sigvant, Birgitt ...; Lundin, Fredrik; Wahlberg, Eric

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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