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Neuroimaging in the...
Neuroimaging in the Kleine-Levin Syndrome
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- Engström, Maria (författare)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Latini, Francesco, 1982- (författare)
- Uppsala universitet,Neurokirurgi,Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden
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- Landtblom, Anne-Marie (författare)
- Linköpings universitet,Uppsala universitet,Neurologi,Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Department of Neuroscience, Section of Neurology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2018-07-21
- 2018
- Engelska.
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Ingår i: Current Neurology and Neuroscience Reports. - Philadelphia, United States : Springer Science and Business Media LLC. - 1528-4042 .- 1534-6293. ; 18:9
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Abstract
Ämnesord
Stäng
- PURPOSE OF REVIEW: The purpose was to review the most recent literature on neuroimaging in the Kleine-Levin syndrome (KLS). We aimed to investigate if frontotemporal and thalamic dysfunction are key KLS signatures, and if recent research indicates other brain networks of interest that elucidate KLS symptomatology and aetiology.RECENT FINDINGS: In a comprehensive literature search, we found 12 original articles published 2013-2018. Most studies report deviations related to cerebral perfusion, glucose metabolism, or blood-oxygen-level-dependent responses in frontotemporal areas and/or the thalamus. Studies also report dysfunction in the temporoparietal junction and the oculomotor network that also were related to clinical parameters. We discuss these findings based on recent research on thalamocortical networks and brain stem white matter tracts. The hypothesis of frontotemporal and thalamic involvement in KLS was confirmed, and additional findings in the temporoparietal junction and the oculomotor system suggest a broader network involvement, which can be investigated by future high-resolution and multimodal imaging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Diffusion weighted imaging (DWI)
- Functional magnetic resonance imaging (fMRI)
- Kleine-Levin syndrome (KLS)
- Magnetic resonance spectroscopy (MRS)
- Positron emission tomography (PET)
- Single photon emission computed tomography (SPECT)
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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