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  • Bejanyan, NelliUniv Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USA (author)

Pretransplant Consolidation Is Not Beneficial for Adults with ALL Undergoing Myeloablative Allogeneic Transplantation

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier BV,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-357580
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357580URI
  • https://doi.org/10.1016/j.bbmt.2017.12.784DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138380338URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Allogeneic hematopoietic cell transplantation (alloHCT) is curative for patients with acute lymphoblastic leukemia (ALL) who achieve complete remission (CR1) with chemotherapy. However, the benefit of consolidation chemotherapy remains uncertain in patients undergoing alloHCT. We compared clinical outcomes of 524 adult patients with ALL in CR1 who received ≥2 (n = 109), 1 (n = 93), or 0 cycles (n = 322) of consolidation before myeloablative alloHCT from 2008 to 2012. As expected, time to alloHCT was longer with increasing cycles of consolidation. Patients receiving ≥2, 1, or 0 cycles of consolidation had an adjusted 3-year cumulative incidence of relapse of 20%, 27%, and 22%; 1-year transplant-related mortality (TRM) of 16%, 18%, and 23%; adjusted 3-year leukemia-free survival (LFS) of 54%, 48%, and 47%; and 3-year overall survival (OS) of 63%, 59%, and 54% (all P values >.40). Multivariable analysis confirmed that consolidation was not prognostic for LFS (relative risk, 1.20, 95% confidence interval, .86 to 1.67; P = .28 for no consolidation; RR, 1.18, 95% confidence interval, .79 to 1.76; P = .41 for 1 cycle versus ≥2 cycles = reference). Similarly, consolidation was not associated with OS, relapse, TRM, or graft-versus-host disease. We conclude that consolidation chemotherapy does not appear to provide added benefit in adult ALL patients with available donors who undergo myeloablative alloHCT in CR1.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhang, Mei-JieMed Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrrow Trasnsplantat, Milwaukee, WI 53226 USA (author)
  • Wang, Hai-LinMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrrow Trasnsplantat, Milwaukee, WI 53226 USA (author)
  • Lazaryan, AleksandrUniv Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USA (author)
  • de Lima, MarcosUniv Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA (author)
  • Marks, David I.Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England (author)
  • Sandmaier, Brenda M.Univ Washington, Div Med Oncol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA (author)
  • Bachanova, VeronikaUniv Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USA (author)
  • Rowe, JacobShaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel (author)
  • Tallman, MartinMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA (author)
  • Kebriaei, PartowUniv Texas MD Anderson Canc Ctr, Div Canc Med, Dept Stem Cell Transplantat, Houston, TX 77030 USA (author)
  • Kharfan-Dabaja, MohamedH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA (author)
  • Gale, Robert PeterImperial Coll London, Div Expt Med, Dept Med, Hematol Res Ctr, London, England (author)
  • Lazarus, Hillard M.Univ Hosp Cleveland Med Ctr, Seidman Canc Ctr, Cleveland, OH USA (author)
  • Ustun, CelalettinUniv Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USA (author)
  • Copelan, EdwardCarolinas HealthCare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA (author)
  • Hamilton, Betty KyCleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA (author)
  • Schiller, GaryUniv Calif Los Angeles, David Geffen Sch Med, Hematol Malignancy Stem Cell Transplant Program, Los Angeles, CA 90095 USA (author)
  • Hogan, WilliamMayo Clin Rochester, Dept Hematol, Rochester, MN USA;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA (author)
  • Hashmi, ShahrukhMayo Clin, Dept Internal Med, Rochester, MN USA;King Faisal Specialist Hosp & Res Ctr, Ctr Oncol, Riyadh, Saudi Arabia (author)
  • Seftel, MatthewCancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada (author)
  • Kanakry, Christopher G.NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA (author)
  • Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden(Swepub:uu)riols677 (author)
  • Martino, RodrigoHosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain (author)
  • Saber, WaelMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrrow Trasnsplantat, Milwaukee, WI 53226 USA (author)
  • Khoury, H. JeanEmory Univ Hosp, 1364 Clifton Rd NE, Atlanta, GA 30322 USA (author)
  • Weisdorf, Daniel J.Univ Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USA (author)
  • Univ Minnesota, Div Hematol Oncol & Transplantat, 420 Delaware St SE,Mayo Mail Code 480, Minneapolis, MN 55455 USAMed Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrrow Trasnsplantat, Milwaukee, WI 53226 USA (creator_code:org_t)

Related titles

  • In:Biology of blood and marrow transplantation: Elsevier BV24:5, s. 945-9551083-87911523-6536

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