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  • Cunningham, Anthony L.Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia (author)

Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-26
  • Oxford University Press,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-357723
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357723URI
  • https://doi.org/10.1093/infdis/jiy095DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background. The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01(B) Adjuvant System, was highly efficacious in preventing herpes zoster in the ZOE-50 and ZOE-70 trials. We present immunogenicity results from those trials. Methods. Participants (ZOE-50: >= 50; ZOE-70: >= 70 years of age) received 2 doses of HZ/su or placebo, 2 months apart. Serum anti-gE antibodies and CD4 T cells expressing >= 2 of 4 activation markers assessed (CD4(2+)) after stimulation with gE-peptides were measured in subcohorts for humoral (n = 3293) and cell-mediated (n = 466) immunogenicity. Results. After vaccination, 97.8% of HZ/su and 2.0% of placebo recipients showed a humoral response. Geometric mean anti-gE antibody concentrations increased 39.1-fold and 8.3-fold over baseline in HZ/su recipients at 1 and 36 months post-dose 2, respectively. A gE-specific CD4(2+) T-cell response was shown in 93.3% of HZ/su and 0% of placebo recipients. Median CD42+ T-cell frequencies increased 24.6-fold (1 month) and 7.9-fold (36 months) over baseline in HZ/su recipients and remained >= 5.6-fold above baseline in all age groups at 36 months. The proportion of CD4 T cells expressing all 4 activation markers increased over time in all age groups. Conclusions. Most HZ/su recipients developed robust immune responses persisting for 3 years following vaccination.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Heineman, Thomas C.GSK, King Of Prussia, PA USA;Genocea Biosci, Cambridge, MA USA (author)
  • Lal, HimalGSK, King Of Prussia, PA USA;Pfizer Inc, Collegeville, PA USA (author)
  • Godeaux, OlivierGSK, Wavre, Belgium;Janssen Vaccines & Prevent, Leiden, Netherlands (author)
  • Chlibek, RomanUniv Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic (author)
  • Hwang, Shinn-JangTaipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan;Natl Yang Ming Univ, Sch Med, Taipei, Taiwan (author)
  • McElhaney, Janet E.Hlth Sci North Res Inst, Sudbury, ON, Canada (author)
  • Vesikari, TimoUniv Tampere, Vaccine Res Ctr, Tampere, Finland (author)
  • Andrews, CharlesDiagnost Res Grp, San Antonio, TX USA (author)
  • Choi, Won SukKorea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea (author)
  • Esen, MeralUniv Clin Tuebingen, Inst Trop Med, Tubingen, Germany (author)
  • Ikematsu, HideyukiJapan Phys Assoc, Chiyoda Ku, Tokyo, Japan (author)
  • Choma, Martina KovacGSK, Rockville, MD USA (author)
  • Pauksen, KarlisUppsala universitet,Infektionssjukdomar(Swepub:uu)karlpauk (author)
  • Ravault, StephanieGSK, Rixensart, Belgium (author)
  • Salaun, BrunoGSK, Rixensart, Belgium (author)
  • Schwarz, Tino F.Standort Juliusspital, Klinikum Wurzburg Mitte, Cent Lab & Vaccinat Ctr, Wurzburg, Germany (author)
  • Smetana, JanUniv Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic (author)
  • Vanden Abeele, CarlineGSK, Wavre, Belgium (author)
  • Van den Steen, PeterGSK, Wavre, Belgium (author)
  • Vastiau, IlseGSK, Wavre, Belgium (author)
  • Weckx, Lily YinUniv Fed Sao Paulo, Sao Paulo, Brazil (author)
  • Levin, Myron J.Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA;Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA (author)
  • Univ Sydney, Westmead Inst Med Res, Sydney, NSW, AustraliaGSK, King Of Prussia, PA USA;Genocea Biosci, Cambridge, MA USA (creator_code:org_t)

Related titles

  • In:Journal of Infectious Diseases: Oxford University Press217:11, s. 1750-17600022-18991537-6613

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