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Immune Responses to...
Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older
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- Cunningham, Anthony L. (author)
- Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia
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- Heineman, Thomas C. (author)
- GSK, King Of Prussia, PA USA;Genocea Biosci, Cambridge, MA USA
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- Lal, Himal (author)
- GSK, King Of Prussia, PA USA;Pfizer Inc, Collegeville, PA USA
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- Godeaux, Olivier (author)
- GSK, Wavre, Belgium;Janssen Vaccines & Prevent, Leiden, Netherlands
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- Chlibek, Roman (author)
- Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic
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- Hwang, Shinn-Jang (author)
- Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan;Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
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- McElhaney, Janet E. (author)
- Hlth Sci North Res Inst, Sudbury, ON, Canada
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- Vesikari, Timo (author)
- Univ Tampere, Vaccine Res Ctr, Tampere, Finland
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- Andrews, Charles (author)
- Diagnost Res Grp, San Antonio, TX USA
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- Choi, Won Suk (author)
- Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea
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- Esen, Meral (author)
- Univ Clin Tuebingen, Inst Trop Med, Tubingen, Germany
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- Ikematsu, Hideyuki (author)
- Japan Phys Assoc, Chiyoda Ku, Tokyo, Japan
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- Choma, Martina Kovac (author)
- GSK, Rockville, MD USA
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- Pauksen, Karlis (author)
- Uppsala universitet,Infektionssjukdomar
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- Ravault, Stephanie (author)
- GSK, Rixensart, Belgium
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- Salaun, Bruno (author)
- GSK, Rixensart, Belgium
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- Schwarz, Tino F. (author)
- Standort Juliusspital, Klinikum Wurzburg Mitte, Cent Lab & Vaccinat Ctr, Wurzburg, Germany
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- Smetana, Jan (author)
- Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic
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- Vanden Abeele, Carline (author)
- GSK, Wavre, Belgium
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- Van den Steen, Peter (author)
- GSK, Wavre, Belgium
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- Vastiau, Ilse (author)
- GSK, Wavre, Belgium
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- Weckx, Lily Yin (author)
- Univ Fed Sao Paulo, Sao Paulo, Brazil
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- Levin, Myron J. (author)
- Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA;Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA
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(creator_code:org_t)
- 2018-02-26
- 2018
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 217:11, s. 1750-1760
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background. The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01(B) Adjuvant System, was highly efficacious in preventing herpes zoster in the ZOE-50 and ZOE-70 trials. We present immunogenicity results from those trials. Methods. Participants (ZOE-50: >= 50; ZOE-70: >= 70 years of age) received 2 doses of HZ/su or placebo, 2 months apart. Serum anti-gE antibodies and CD4 T cells expressing >= 2 of 4 activation markers assessed (CD4(2+)) after stimulation with gE-peptides were measured in subcohorts for humoral (n = 3293) and cell-mediated (n = 466) immunogenicity. Results. After vaccination, 97.8% of HZ/su and 2.0% of placebo recipients showed a humoral response. Geometric mean anti-gE antibody concentrations increased 39.1-fold and 8.3-fold over baseline in HZ/su recipients at 1 and 36 months post-dose 2, respectively. A gE-specific CD4(2+) T-cell response was shown in 93.3% of HZ/su and 0% of placebo recipients. Median CD42+ T-cell frequencies increased 24.6-fold (1 month) and 7.9-fold (36 months) over baseline in HZ/su recipients and remained >= 5.6-fold above baseline in all age groups at 36 months. The proportion of CD4 T cells expressing all 4 activation markers increased over time in all age groups. Conclusions. Most HZ/su recipients developed robust immune responses persisting for 3 years following vaccination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- varicella-zoster virus
- herpes zoster vaccine
- gE subunit vaccine
- adjuvant system
- immunogenicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cunningham, Anth ...
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Heineman, Thomas ...
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Lal, Himal
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Godeaux, Olivier
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Chlibek, Roman
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Hwang, Shinn-Jan ...
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show more...
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McElhaney, Janet ...
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Vesikari, Timo
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Andrews, Charles
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Choi, Won Suk
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Esen, Meral
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Ikematsu, Hideyu ...
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Choma, Martina K ...
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Pauksen, Karlis
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Ravault, Stephan ...
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Salaun, Bruno
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Schwarz, Tino F.
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Smetana, Jan
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Vanden Abeele, C ...
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Van den Steen, P ...
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Vastiau, Ilse
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Weckx, Lily Yin
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Levin, Myron J.
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MEDICAL AND HEAL ...
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Uppsala University