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  • Rank, Cecilie UtkeUniv Copenhagen, Rigshosp, Pediat Oncol Res Lab, Copenhagen, Denmark;Univ Copenhagen, Rigshosp, Dept Hematol, Copenhagen, Denmark (författare)

Thromboembolism in acute lymphoblastic leukemia : results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • AMER SOC HEMATOLOGY,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-358085
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358085URI
  • https://doi.org/10.1182/blood-2018-01-827949DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during the treatment of 1772 consecutive Nordic/Baltic patients with ALL aged 1 to 45 years who were treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol (July 2008-April 2017). The 2.5-year cumulative incidence of thromboembolism (N = 137) was 7.9% (95% confidence interval [CI], 6.6-9.1); it was higher in patients aged at least 10 years (P < .0001). Adjusted hazard ratios (HRas) were associated with greater age (range, 10.0-17.9 years: HRa, 4.9 [95% CI, 3.1-7.8; P < .0001]; 18.0-45.9 years: HRa, 6.06 [95% CI, 3.65-10.1; P < .0001]) and mediastinal mass at ALL diagnosis (HRa, 2.1; 95% CI, 1.0-4.3; P = .04). In a multiple absolute risk regression model addressing 3 thromboembolism risk factors, age at least 10 years had the largest absolute risk ratio (RRage, 4.7 [95% CI, 3.1-7.1]; RRenlarged (lymph nodes), 2.0 [95% CI, 1.2-3.1]; RRmediastinal mass, 1.6 [95% CI, 1.0-2.6]). Patients aged 18.0 to 45.9 years had an increased hazard of pulmonary embolism (HRa, 11.6; 95% CI, 4.02-33.7; P < .0001), and patients aged 10.0 to 17.9 years had an increased hazard of cerebral sinus venous thrombosis (HRa, 3.3; 95% CI, 1.5-7.3; P = .003) compared with children younger than 10.0 years. Asparaginase was truncated in 38/128 patients with thromboembolism, whereas thromboembolism diagnosis was unassociated with increased hazard of relapse (P = .6). Five deaths were attributable to thromboembolism, and patients younger than 18.0 years with thromboembolism had increased hazard of dying compared with same-aged patients without thromboembolism (both P <= .01). In conclusion, patients aged at least 10 years could be candidates for preemptive antithrombotic prophylaxis. However, the predictive value of age 10 years or older, enlarged lymph nodes, and mediastinal mass remain to be validated in another cohort.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Toft, NinaUniv Copenhagen, Rigshosp, Dept Hematol, Copenhagen, Denmark (författare)
  • Tuckuviene, RutaAalborg Univ Hosp, Dept Pediat, Aalborg, Denmark (författare)
  • Grell, KathrineUniv Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark (författare)
  • Nielsen, Ove JuulUniv Copenhagen, Rigshosp, Dept Hematol, Copenhagen, Denmark (författare)
  • Frandsen, Thomas LethUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark (författare)
  • Marquart, Hanne Vibeke HansenUniv Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark (författare)
  • Albertsen, Birgitte KlugAarhus Univ Hosp, Dept Pediat, Aarhus, Denmark (författare)
  • Tedgard, UlfLund Univ Hosp, Dept Pediat & Coagulat Disorders, Malmo, Sweden (författare)
  • Hallböök, HeleneUppsala universitet,Hematologi(Swepub:uu)helehall (författare)
  • Ruud, EllenOslo Univ Hosp, Rikshosp, Dept Paediat Med, Oslo, Norway (författare)
  • Jarvis, Kirsten BrunsvigOslo Univ Hosp, Rikshosp, Dept Paediat Med, Oslo, Norway (författare)
  • Quist-Paulsen, PetterTrondheim Reg & Univ Hosp, St Olavs Hosp, Dept Hematol, Trondheim, Norway (författare)
  • Huttunen, PasiHelsinki Univ Hosp, Childrens Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Helsinki, Finland (författare)
  • Wartiovaara-Kautto, UllaHelsinki Univ Hosp, Ctr Comprehens Canc, Dept Hematol, Helsinki, Finland;Univ Helsinki, Helsinki, Finland (författare)
  • Jonsson, Olafur GisliUniv Hosp, Landspitali, Childrens Hosp, Reykjavik, Iceland (författare)
  • Trakymiene, Sonata SaulyteVilnius Univ Hosp Santaros Klin, Childrens Hosp, Ctr Pediat Oncol & Hematol, Vilnius, Lithuania (författare)
  • Griskevicius, LaimonasVilnius Univ Hosp Santaros Klin, Dept Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania;Vilnius Univ, Vilnius, Lithuania (författare)
  • Saks, KadriTallinn Childrens Hosp, Dept Oncohematol, Tallinn, Estonia (författare)
  • Punab, MariTartu Univ Hosp, Dept Hematol & Oncol, Tartu, Estonia (författare)
  • Schmiegelow, KjeldUniv Copenhagen, Rigshosp, Pediat Oncol Res Lab, Copenhagen, Denmark;Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark (författare)
  • Univ Copenhagen, Rigshosp, Pediat Oncol Res Lab, Copenhagen, Denmark;Univ Copenhagen, Rigshosp, Dept Hematol, Copenhagen, DenmarkUniv Copenhagen, Rigshosp, Dept Hematol, Copenhagen, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Blood: AMER SOC HEMATOLOGY131:22, s. 2475-24840006-49711528-0020

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  • Blood (Sök värdpublikationen i LIBRIS)

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