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Neutrophil Gelatina...
Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy : A Systematic Review and Meta-analysis
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- Albert, Christian (författare)
- Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany.;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.
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- Zapf, Antonia (författare)
- Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany.
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- Haase, Michael (författare)
- Otto von Guericke Univ, Fac Med, Magdeburg, Germany.;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.
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visa fler...
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- Rover, Christian (författare)
- Univ Med Ctr Gottingen, Dept Med Stat, Gottingen, Germany.
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- Pickering, John W. (författare)
- Univ Otago Christchurch, Dept Med, Christchurch, New Zealand.;Christchurch Hosp, Emergency Dept, Christchurch, New Zealand.
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- Albert, Annemarie (författare)
- Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.;Klinikum Ernst von Bergmann, Dept Nephrol & Endocrinol, Potsdam, Germany.
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- Bellomo, Rinaldo (författare)
- Austin Hosp, Dept Intens Care, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Integrated Crit Care, Melbourne, Vic, Australia.
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- Breidthardt, Tobias (författare)
- Univ Hosp Basel, Dept Internal Med, Basel, Switzerland.;Univ Hosp Basel, Dept Nephrol, Basel, Switzerland.;Univ Hosp Basel, Dept Cardiol, Basel, Switzerland.
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- Camou, Fabrice (författare)
- CHU Bordeaux, Hop St Andre, Serv Reanimat Med, Bordeaux, France.
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- Chen, Zhongquing (författare)
- Southern Med Univ, Nanfang Hosp, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China.
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- Chocron, Sidney (författare)
- Univ Hosp Jean Minjoz, Dept Thorac & Cardiovasc Surg, Besancon, France.
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- Cruz, Dinna (författare)
- Univ Calif San Diego, Div Nephrol Hypertens, San Diego, CA 92103 USA.
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- de Geus, Hilde R. H. (författare)
- Erasmus MC, Dept Intens Care, Rotterdam, Netherlands.
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- Devarajan, Prasad (författare)
- Univ Cincinnati, Div Nephrol & Hypertens, Cincinnati Childrens Hosp, Cincinnati, OH USA.
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- Di Somma, Salvatore (författare)
- Univ Rome, Dept Med Surg Sci & Translat Med, Emergency Med, S Andrea Hosp, Rome, Italy.
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- Doi, Kent (författare)
- Univ Tokyo, Dept Emergency & Crit Care Med, Tokyo, Japan.
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- Endre, Zoltan H. (författare)
- Univ New South Wales, Prince Wales Hosp, Dept Nephrol, Sydney, NSW, Australia.;Univ New South Wales, Clin Sch, Dept Nephrol, Sydney, NSW, Australia.
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- Garcia-Alvarez, Mercedes (författare)
- Hosp Santa Creu Sant & Pau, Dept Anesthesiol, Barcelona, Spain.
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- Hjortrup, Peter B. (författare)
- Copenhagen Univ Hosp, Dept Intens Care, Copenhagen, Denmark.
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- Hur, Mina (författare)
- Konkuk Univ, Dept Lab Med, Sch Med, Seoul, South Korea.
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- Karaolanis, Georgios (författare)
- Natl & Kapodistrian Univ Athens, Med Sch, Laiko Gen Hosp, Vasc Unit,Dept Surg 1, Athens, Greece.
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- Kavalci, Cemil (författare)
- Baskent Univ, Emergency Dept, Fac Med, Ankara, Turkey.
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- Kim, Hanah (författare)
- Konkuk Univ, Dept Lab Med, Sch Med, Seoul, South Korea.
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- Lentini, Paolo (författare)
- San Bassiano Hosp, Dept Nephrol & Dialysis, Bassano Del Grappa, Italy.
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- Liebetrau, Christoph (författare)
- Kerckhoff Clin, Dept Cardiol, Bad Nauheim, Germany.
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- Lipcsey, Miklós (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Martensson, Johan (författare)
- Karolinska Institutet
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- Mueller, Christian (författare)
- Univ Hosp Basel, Dept Internal Med, Basel, Switzerland.;Univ Hosp Basel, Dept Nephrol, Basel, Switzerland.;Univ Hosp Basel, Dept Cardiol, Basel, Switzerland.
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- Nanas, Serafim (författare)
- Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Crit Care Dept 1, Athens, Greece.
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- Nickolas, Thomas L. (författare)
- Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA.
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- Pipili, Chrysoula (författare)
- Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Crit Care Dept 1, Athens, Greece.
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- Ronco, Claudio (författare)
- Univ Padua, Nephrol Dialysis & Transplantat, Padua, Italy.;San Bortolo Hosp, Int Renal Res Inst, Vicenza, Italy.
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- Rosa-Diez, Guillermo J. (författare)
- Hosp Italiano Buenos Aires, Dept Nephrol Dialysis & Transplantat, Buenos Aires, DF, Argentina.
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- Ralib, Azrina (författare)
- Int Islamic Univ Malaysia, Dept Anaesthesiol & Intens Care, Pahang, Malaysia.
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- Soto, Karina (författare)
- Hosp Fernando Fonseca, Dept Nephrol, Amadora, Portugal.;Univ Lisbon, Ctr Estat & Aplicacoes, CEAUL, Lisbon, Portugal.
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- Braun-Dullaeus, Ruediger C. (författare)
- Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany.
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- Heinz, Judith (författare)
- Univ Med Ctr Gottingen, Dept Med Stat, Gottingen, Germany.
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- Haase-Fielitz, Anja (författare)
- Univ Potsdam, Brandenburg Med Sch Theodor Fontane, Immanuel Diakonie Bernau, Heart Ctr Brandenburg,Dept Cardiol,Fac Hlth Sci, Potsdam, Germany.
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Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany. Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany. (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: American Journal of Kidney Diseases. - : Elsevier BV. - 0272-6386 .- 1523-6838. ; 76:6, s. 826-
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Rationale & Objective: The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction.Study Design: Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines.Setting & Study Populations: Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platforms.Selection Criteria for Studies: PubMed, Web of Science, Cochrane Library, Scopus, and congress abstracts ever published through February 2020 reporting diagnostic test studies of NGAL measured on clinical laboratory platforms to predict AKI.Data Extraction: Individual-study-data meta analysis was accomplished by giving authors data specifications tailored to their studies and requesting standardized patient-level data analysis.Analytical Approach: Individual-study-data meta analysis used a bivariate time-to-event model for interval-censored data from which discriminative ability (AUC) was characterized. NGAL cutoff concentrations at 95% sensitivity, 95% specificity, and optimal sensitivity and specificity were also estimated. Models incorporated as confounders the clinical setting and use versus nonuse of urine output as a criterion for AKI. A literature-based meta-analysis was also performed for all published studies including those for which the authors were unable to provide individual-study data analyses.Results: We included 52 observational studies involving 13,040 patients. We analyzed 30 data sets for the individual-study-data meta-analysis. For AKI, severe AKI, and AKI-D, numbers of events were 837, 304, and 103 for analyses of urinary NGAL, respectively; these values were 705, 271, and 178 for analyses of plasma NGAL. Discriminative performance was similar in both meta-analyses. Individual-study-data meta-analysis AUCs for urinary NGAL were 0.75 (95% CI, 0.73-0.76) and 0.80 (95% CI, 0.79-0.81) for severe AKI and AKI-D, respectively; for plasma NGAL, the corresponding AUCs were 0.80 (95% CI, 0.790.81) and 0.86 (95% CI, 0.84-0.8 6). Cutoff concentrations at 95% specificity for urinary NGAL were >580 ng/mL with 27% sensitivity for severe AKI and >589 ng/mL with 24% sensitivity for AKI-D. Corresponding cutoffs for plasma NGAL were >364 ng/mL with 44% sensitivity and >546 ng/mL with 26% sensitivity, respectively.Limitations: Practice variability in initiation of dialysis. Imperfect harmonization of data across studies. Conclusions: Urinary and plasma NGAL concentrations may identify patients at high risk for AKI in clinical research and practice. The cutoff concentrations reported in this study require prospective evaluation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Albert, Christia ...
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Zapf, Antonia
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Haase, Michael
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Rover, Christian
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Pickering, John ...
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Albert, Annemari ...
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Bellomo, Rinaldo
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Breidthardt, Tob ...
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Camou, Fabrice
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Chen, Zhongquing
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Chocron, Sidney
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Cruz, Dinna
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de Geus, Hilde R ...
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Devarajan, Prasa ...
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Di Somma, Salvat ...
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Doi, Kent
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Endre, Zoltan H.
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Garcia-Alvarez, ...
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Hjortrup, Peter ...
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Hur, Mina
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Karaolanis, Geor ...
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Kavalci, Cemil
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Kim, Hanah
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Lentini, Paolo
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Liebetrau, Chris ...
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Lipcsey, Miklós
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Martensson, Joha ...
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Mueller, Christi ...
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Nanas, Serafim
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Nickolas, Thomas ...
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Ronco, Claudio
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Ralib, Azrina
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