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Prognostic Impact o...
Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer : A Prospective Multicentre Validation Study
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- Dyrskjot, Lars (författare)
- Aarhus Univ Hosp, Dept Mol Med, Palle Juul Jensens Blvd, DK-8200 Aarhus N, Denmark
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- Reinert, Thomas (författare)
- Aarhus Univ Hosp, Dept Mol Med, Palle Juul Jensens Blvd, DK-8200 Aarhus N, Denmark
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- Algaba, Ferran (författare)
- Univ Autonoma Barcelona, Sect Pathol, Fundacio Puigvert, Barcelona, Spain
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- Christensen, Emil (författare)
- Aarhus Univ Hosp, Dept Mol Med, Palle Juul Jensens Blvd, DK-8200 Aarhus N, Denmark
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- Nieboer, Daan (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
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- Hermann, Gregers G. (författare)
- Frederiksberg Univ Hosp, Dept Urol, Frederiksberg, Denmark
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- Mogensen, Karin (författare)
- Frederiksberg Univ Hosp, Dept Urol, Frederiksberg, Denmark
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- Beukers, Willemien (författare)
- Erasmus MC, Dept Pathol, Rotterdam, Netherlands
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- Marquez, Mirari (författare)
- Spanish Natl Canc Res Ctr, Madrid, Spain
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- Segersten, Ulrika (författare)
- Uppsala universitet,Urologkirurgi
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- Hoyer, Soren (författare)
- Aarhus Univ Hosp, Dept Pathol, Aarhus, Denmark
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- Ulhoi, Benedicte P. (författare)
- Aarhus Univ Hosp, Dept Pathol, Aarhus, Denmark
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- Hartmann, Arndt (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany
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- Stohr, Robert (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany
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- Wach, Sven (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Urol, Erlangen, Germany
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- Nawroth, Roman (författare)
- Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany
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- Schwamborn, Kristina (författare)
- Tech Univ Munich, Inst Pathol, Klinikum Rechts Isar, Munich, Germany
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- Tulic, Cane (författare)
- Univ Belgrade, Clin Ctr Serbia, Clin Urol, Fac Med, Belgrade, Serbia
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- Simic, Tatjana (författare)
- Univ Belgrade, Inst Med & Clin Biochem, Fac Med, Belgrade, Serbia
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- Junker, Kerstin (författare)
- Saarland Univ, Dept Urol, Homburg, Germany
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- Harving, Niels (författare)
- Aalborg Univ Hosp, Dept Urol, Aalborg, Denmark
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- Petersen, Astrid C. (författare)
- Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark
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- Jensen, Jorgen B. (författare)
- Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark
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- Keck, Bastian (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Urol, Erlangen, Germany
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- Grimm, Marc-Oliver (författare)
- Friedrich Schiller Univ Jena, Dept Urol, Jena, Germany
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- Horstmann, Marcus (författare)
- Friedrich Schiller Univ Jena, Dept Urol, Jena, Germany
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- Maurer, Tobias (författare)
- Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany
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- Steyerberg, Ewout W. (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
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- Zwarthoff, Ellen C. (författare)
- Erasmus MC, Dept Pathol, Rotterdam, Netherlands
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- Real, Francisco X. (författare)
- Spanish Natl Canc Res Ctr, Madrid, Spain;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain
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- Malats, Nuria (författare)
- Spanish Natl Canc Res Ctr, Madrid, Spain
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- Malmström, Per-Uno (författare)
- Uppsala universitet,Urologkirurgi
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- Orntoft, Torben F. (författare)
- Aarhus Univ Hosp, Dept Mol Med, Palle Juul Jensens Blvd, DK-8200 Aarhus N, Denmark
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 72:3, s. 461-469
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is life-threatening and cannot be accurately predicted using clinical and pathological risk factors. Biomarkers for stratifying patients to treatment and surveillance are greatly needed. Objective: To validate a previously developed 12-gene progression score to predict progression to MIBC in a large, multicentre, prospective study. Design, setting, and participants: We enrolled 1224 patients in ten European centres between 2008 and 2012. A total of 750 patients (851 tumours) fulfilled the inclusion and sample quality criteria for testing. Patients were followed for an average of 28 mo (range 0-76). A 12-gene real-time qualitative polymerase chain reaction assay was performed for all tumours and progression scores were calculated using a predefined formula and cut-off values. Outcome measurements and statistical analysis: We measured progression to MIBC using Cox regression analysis and log-rank tests for comparing survival distributions. Results and limitations: The progression score was significantly (p < 0.001) associated with age, stage, grade, carcinoma in situ, bacillus Calmette-Guerin treatment, European Organisation for Research and Treatment of Cancer risk score, and disease progression. Univariate Cox regression analysis showed that patients molecularly classified as high risk experienced more frequent disease progression (hazard ratio 5.08, 95% confidence interval 2.2-11.6; p < 0.001). Multivariable Cox regression models showed that the progression score added independent prognostic information beyond clinical and histopathological risk factors (p < 0.001), with an increase in concordance statistic from 0.82 to 0.86. The progression score showed high correlation (R-2 = 0.85) between paired fresh-frozen and formalin-fixed paraffin-embedded tumour specimens, supporting translation potential in the standard clinical setting. A limitation was the relatively low progression rate (5%, 37/ 750 patients). Conclusions: The 12-gene progression score had independent prognostic power beyond clinical and histopathological risk factors, and may help in stratifying NMIBC patients to optimise treatment and follow-up regimens. Patient summary: Clinical use of a 12-gene molecular test for disease aggressiveness may help in stratifying patients with non-muscle-invasive bladder cancer to optimal treatment regimens.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Bladder cancer
- Non-muscle-invasive bladder cancer
- Prognostic biomarker
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Dyrskjot, Lars
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Reinert, Thomas
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Algaba, Ferran
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Christensen, Emi ...
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Nieboer, Daan
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Hermann, Gregers ...
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visa fler...
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Mogensen, Karin
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Beukers, Willemi ...
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Marquez, Mirari
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Segersten, Ulrik ...
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Hoyer, Soren
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Ulhoi, Benedicte ...
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Hartmann, Arndt
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Stohr, Robert
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Wach, Sven
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Nawroth, Roman
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Schwamborn, Kris ...
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Tulic, Cane
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Simic, Tatjana
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Junker, Kerstin
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Harving, Niels
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Petersen, Astrid ...
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Jensen, Jorgen B ...
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Keck, Bastian
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Grimm, Marc-Oliv ...
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Horstmann, Marcu ...
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Maurer, Tobias
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Steyerberg, Ewou ...
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Zwarthoff, Ellen ...
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Real, Francisco ...
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Malats, Nuria
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Malmström, Per-U ...
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Orntoft, Torben ...
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European Urology
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