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  • Siroux, V.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (författare)

The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-02-06
  • WILEY,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-359883
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359883URI
  • https://doi.org/10.1111/all.13410DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138545086URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundChildren with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity.MethodsIgE reactivity to 64 micro-arrayed aeroallergen molecules was determined with the MeDALL-chip in samples from the French EGEA study (n = 840, age = 40.7 17.1) and the Swedish population-based birth cohort BAMSE (n = 786, age = 16 0.26). The age- and sex-adjusted associations between the number of IgE-reactive allergen molecules (0.3 ISU) and the asthma-rhinitis phenotypes were assessed using a negative binomial model.ResultsGroups representing 4 phenotypes were identified: no asthma-no rhinitis (A-R-; 30% in EGEA and 54% in BAMSE), asthma alone (A+R-; 11% and 8%), rhinitis alone (A-R+; 15% and 24%) and asthma-rhinitis (A+R+; 44% and 14%). The numbers of IgE-reactive aeroallergen molecules significantly differed between phenotypes (median in A-R-, A+R-, A-R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE). As compared to A-R- subjects, the adjusted ratio of the mean number of IgE-reactive molecules was higher in A+R+ than in A+R- or A-R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE). ConclusionThe A+R+ phenotype combined the sensitization pattern of both the A-R+ and A+R- phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ballardini, N.Karolinska Institutet (författare)
  • Soler, M.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (författare)
  • Lupinek, C.Med Univ Vienna, Dept Pathophysiol & Allergy Res, Div Immunopathol, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria (författare)
  • Boudier, A.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (författare)
  • Pin, I.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France;CHU Grenoble Alpes, Dept Pediat, Grenoble, France (författare)
  • Just, J.Children Hosp Armand Trousseau, Allergol Dept, Paris, France;UPMC, INSERM, UMR S 1136, Paris, France (författare)
  • Nadif, R.INSERM, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France (författare)
  • Anto, J. M.Ctr Res Environm Epidemiol CREAL, ISGLoBAL, Barcelona, Spain (författare)
  • Melen, E.Karolinska Institutet (författare)
  • Valenta, R.Med Univ Vienna, Dept Pathophysiol & Allergy Res, Div Immunopathol, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria;NRC Inst Immunol FMBA Russia, Moscow, Russia (författare)
  • Wickman, MagnusUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Inst Environm Med, Stockholm, Sweden;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden (författare)
  • Bousquet, J.INSERM, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France (författare)
  • Karolinska InstitutetUniv Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Allergy. European Journal of Allergy and Clinical Immunology: WILEY73:7, s. 1447-14580105-45381398-9995

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