SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:uu-360175"
 

Search: id:"swepub:oai:DiVA.org:uu-360175" > Synthesis of aryl p...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Channar, Pervaiz AliQuaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan (author)

Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • ACADEMIC PRESS INC ELSEVIER SCIENCE,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-360175
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-360175URI
  • https://doi.org/10.1016/j.bioorg.2018.04.026DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aryl pyrazoles are well recognized class of heterocyclic compounds found in several commercially available drugs. Owing to their significance in medicinal chemistry, in this current account we have synthesized a series of suitably substituted aryl pyrazole by employing Suzuki cross-coupling reaction. All compounds were evaluated for inhibition of mushroom tyrosinase enzyme both in vitro and in silico. Compound 3f (IC50 = 1.568 +/- 0.01 mu M) showed relatively better potential compared to reference kojic acid (IC50 = 16.051 +/- 1.27 mu M). A comparative docking studies showed that compound 3f have maximum binding affinity against mushroom tyrosinase (PDBID: 2Y9X) with binding energy value (-6.90 kcal/mol) as compared to Kojic acid. The 4-methoxy group in compound 3f shows 100% interaction with Cu. Compound 3f displayed hydrogen binding interaction with His61 and His94 at distance of 1.71 and 1.74 angstrom which might be responsible for higher activity compared to Kojic acid.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Saeed, AamerQuaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan (author)
  • Larik, Fayaz AliQuaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan (author)
  • Batool, BakhtawarQuaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan (author)
  • Kalsoom, SaimaInt Islamic Univ, SA CIRBS, Islamabad, Pakistan (author)
  • Hasan, M. M.PIEAS, Islamabad, Pakistan (author)
  • Erben, Mauricio F.UNLP, CONICET, Fac Ciencias Exactas, CEQUINOR,CCT La Plata,Dept Quim, CC 962, RA-1900 La Plata, Buenos Aires, Argentina (author)
  • El-Seedi, HeshamUppsala universitet,Farmakognosi(Swepub:uu)heels173 (author)
  • Ali, MusratQuaid I Azam Univ, Dept Biol Sci, Islamabad 45320, Pakistan (author)
  • Ashraf, ZamanAllama Iqbal Open Univ, Dept Chem, Islamabad 44000, Pakistan (author)
  • Quaid I Azam Univ, Dept Chem, Islamabad 45320, PakistanInt Islamic Univ, SA CIRBS, Islamabad, Pakistan (creator_code:org_t)

Related titles

  • In:Bioorganic chemistry (Print): ACADEMIC PRESS INC ELSEVIER SCIENCE79, s. 293-3000045-2068

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view