WFRF:(Carvalho Eugenia)
Sökning: WFRF:(Carvalho Eugenia) > Identification and ...
Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery
-
- Cruz Oliveira Pinho, Aryane (författare)
- Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.;Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.;Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3000456 Coimbra, Portugal.
-
- Barbosa, Pedro (författare)
- Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.;Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res, P-3030789 Coimbra, Portugal.
-
- Lazaro, André (författare)
- Univ Coimbra, Ctr Hosp Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.
- visa fler...
- visa färre...
- Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal;Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.;Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3000456 Coimbra, Portugal. Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.;Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res, P-3030789 Coimbra, Portugal. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
- Ingår i: Immunology Letters. - : Elsevier. - 0165-2478 .- 1879-0542. ; 269
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- T cells play critical roles in adipose tissue (AT) inflammation. The role of CD20+ T cell in AT dysfunction and their contributing to insulin resistance (IR) and type 2 diabetes progression, is not known. The aim was to characterize CD20+ T cells in omental (OAT), subcutaneous (SAT) and peripheral blood (PB) from subjects with obesity (OB, n = 42), by flow cytometry. Eight subjects were evaluated before (T1) and 12 months post (T2) bariatric/metabolic surgery (BMS). PB from subjects without obesity (nOB, n = 12) was also collected. Higher percentage of CD20+ T cells was observed in OAT, compared to PB or SAT, in OB-T1. CD20 expression by PB CD4+ T cells was inversely correlated with adiposity markers, while follicular-like CD20+ T cells were positively correlated with impaired glucose tolerance (increased HbA1c). Notably, among OB-T1, IR establishment was marked by a lower percentage and absolute number of PB CD20+ T cells, compared nOB. Obesity was associated with higher percentage of activated CD20+ T cells; however, OAT-infiltrated CD20+ T cells from OB-T1 with diabetes displayed the lowest activation. CD20+ T cells infiltrating OAT from OB-T1 displayed a phenotype towards IFN-γ-producing Th1 and Tc1 cells. After BMS, the percentage of PB CD4+CD20+ T cells increased, with reduced Th1 and increased Th17 phenotype. Whereas in OAT the percentage of CD20+ T cells with Th1/17 and Tc1/17 phenotypes increased. Interestingly, OAT from OB pre/post BMS maintained higher frequency of effector memory CD20+ T cells. In conclusion, CD20+ T cells may play a prominent role in obesity-related AT inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- CD20+T cells
- Adipose tissue
- Obesity
- Insulin resistance
- Bariatric surgery
- Flow cytometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Cruz Oliveira Pi ...
- Barbosa, Pedro
- Lazaro, André
- Tralhão, José G.
- João Pereira, Ma ...
- Paiva, Artur
- visa fler...
- Laranjeira, Paul ...
- Carvalho, Eugeni ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Endokrinologi oc ...
- Artiklar i publikationen
- Immunology Lette ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
