Validation of SmartPill® wireless motility capsule for gastrointestinaltransit time: Intra-subject variability, software accuracy and comparison with video capsule endoscopy

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Diaz Tartera, Hetzel O.Uppsala universitet,Gastroenterologi/hepatologi (author)

Validation of SmartPill® wireless motility capsule for gastrointestinaltransit time : Intra-subject variability, software accuracy and comparison with video capsule endoscopy

Article/chapterEnglish2017

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2017-05-19
Wiley,2017
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LIBRIS-ID:oai:DiVA.org:uu-322579
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322579URI
https://doi.org/10.1111/nmo.13107DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136596637URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: There is interest in ultimately combining endoscopy and motility assessments. Gastric emptying (GET), small bowel (SBTT), colon (CTT) and whole gut transit (WGTT) times are conveniently obtained by SmartPill® wireless motility capsule (WMC) that records luminal pH, temperature and pressure. Reproducibility within same subjects and accuracy of software derived times (MotiliGI® ) were investigated for diagnostic application. GET and SBTT were separately measured using video capsule endoscopy (VCE). The aim of this investigation was to assess same subject reproducibility of WMC, accuracy of software derived transit times and relate to Pillcam® SB (small bowel) VCE motility data.METHODS: Seventy three healthy adults ingested a 260 kcal mixed meal followed by WMC tests. Food intake was permitted after 6 hours. Regional transit data was obtained for GET, SBTT and CTT, the sum yielding WGTT. Nineteen subjects repeated WMC tests 2 or 4 weeks later; a separate 70 underwent VCE while fasted.KEY RESULTS: Visually derived data from WMC yielded GET 3.46±0.27, SBTT 5.15±0.21, CTT 20.76±1.19 and WGTT 29.53±1.28 hours (mean±SEM). Pearson's correlation coefficients (r) against software derived results were: GET 0.78 (P<.0001), SBTT 0.28 (P<.05), CTT 0.96 (P<.0001), WGTT 0.99 (P<.0001). VCE yielded lower GET (0.71±0.08 hours) and SBTT (4.15±0.13 hours).CONCLUSIONS AND INFERENCES: GET, SBTT, CTT and WGTT obtained by WMC are commensurate with literature values, including by other methods. Visually and software derived transit times have strongest correlations for CTT and WGTT. WMC yields longer GET and SBTT than VCE, perhaps due to meal related effects on motility.

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Webb, Dominic-LucUppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)domwe127 (author)
Al-Saffar, Anas,1969-Uppsala universitet,Gastroenterologi/hepatologi,Uppsala University(Swepub:uu)anaal104 (author)
Halim, Mohammed Abdul,1983-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)abdab535 (author)
Lindberg, GKarolinska Institutet (author)
Sangfelt, PerUppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)persangf (author)
Hellström, Per M.,1954-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)perhe742 (author)
Uppsala universitetGastroenterologi/hepatologi (creator_code:org_t)

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In:Neurogastroenterology and Motility: Wiley29:101350-19251365-2982

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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By the university: Uppsala University; Karolinska Institutet

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