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Persistence of immu...
Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults
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- Schwarz, Tino F. (författare)
- Standort Juliusspital, Klinikum Wurzburg Mitte, Lab Med & Vaccinat, Wurzburg, Germany
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- Volpe, Stephanie (författare)
- GSK, Clin R&D, Wavre, Belgium
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- Catteau, Gregory (författare)
- GSK, R&D, Clin Evidence Generat, Biostat & Stat Programming, Wavre, Belgium
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- Chlibek, Roman (författare)
- Univ Def, Fac Mil Hlth Sci, Dept Epidemiol, Hradec Kralove, Czech Republic
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- David, Marie Pierre (författare)
- GSK, R&D, Clin Evidence Generat, Biostat & Stat Programming, Rixensart, Belgium
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- Richardus, Jan Hendrik (författare)
- Municipal Publ Hlth Serv Rotterdam Rijnmond, Dept Infect Dis Control, Rotterdam, Netherlands
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- Lal, Himal (författare)
- Pfizer Inc, Clin R&D, Collegeville, PA USA
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- Oostvogels, Lidia (författare)
- GSK, Clin R&D, Wavre, Belgium
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- Pauksens, Karlis (författare)
- Uppsala Univ Hosp, Infect Dis Sect, Med Sci, Uppsala, Sweden
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- Ravault, Stephanie (författare)
- GSK, Clin Lab Sci, Rixensart, Belgium
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- Rombo, Lars (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Centrum för klinisk forskning i Sörmland (CKFD)
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- Sonder, Gerard (författare)
- Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands
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- Smetana, Jan (författare)
- Univ Def, Fac Mil Hlth Sci, Dept Epidemiol, Hradec Kralove, Czech Republic
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- Heineman, Thomas (författare)
- Genocea Biosci, Clin Dev, Cambridge, MA USA
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- Bastidas, Adriana (författare)
- GSK, Clin R&D, Wavre, Belgium
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(creator_code:org_t)
- 2018-03-21
- 2018
- Engelska.
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Ingår i: Human Vaccines & Immunotherapeutics. - : TAYLOR & FRANCIS INC. - 2164-5515 .- 2164-554X. ; 14:6, s. 1370-1377
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In adults aged 60years, two doses of the herpes zoster subunit vaccine (HZ/su; 50 mu g varicella-zoster virus glycoprotein E [gE] and AS01(B) Adjuvant System) elicited humoral and cell-mediated immune responses persisting for at least six years. We assessed immunogenicity nine years post-initial vaccination.Methods: This open extension study (NCT02735915) followed 70 participants who received two HZ/su doses in the initial trial (NCT00434577). Blood samples to assess the cellular (intracellular cytokine staining) and humoral (ELISA) immunity were taken at year nine post-initial vaccination.Results: Participants' mean age at dose 1 was 72.3years. The fold increases over pre-vaccination in the mean frequency of gE-specific CD4+ T-cells expressing 2 activation markers plateaued from year four post-dose 1 until year nine. Anti-gE antibody geometric mean concentrations plateaued and remained above pre-vaccination levels from year four onwards. Immunogenicity at year nine was similar across age strata (60-69, 70years) and confirmed statistical prediction model results using data for up to year six. Further modeling using all data up to year nine predicted immune responses would remain above the pre-vaccination level up to year 15.Conclusion: In adults aged 60years, HZ/su-induced immunogenicity remained above pre-vaccination levels for at least nine years post-initial vaccination.Summary: After vaccination with HZ/su, both cell mediated and humoral immunity remained above pre-vaccination levels up to year 9 regardless of age group. Immune responses are predicted to remain above baseline up to 15years post initial vaccination.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- herpes zoster (shingles) vaccine
- herpes zoster
- immunity
- persistence
- prediction modeling
- prevention
- subunit gE vaccine
- varicella-zoster virus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Schwarz, Tino F.
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Volpe, Stephanie
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Catteau, Gregory
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Chlibek, Roman
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David, Marie Pie ...
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Richardus, Jan H ...
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Lal, Himal
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Oostvogels, Lidi ...
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Pauksens, Karlis
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Ravault, Stephan ...
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Rombo, Lars
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Sonder, Gerard
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Smetana, Jan
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Heineman, Thomas
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Bastidas, Adrian ...
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