WFRF:(Strömstedt Adam A. Dr 1977 )
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- Nyström, LinaUppsala universitet,Institutionen för farmaci (author)
Avidin-biotin cross-linked microgel multilayers as carriers for antimicrobial peptides
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-11-14
- American Chemical Society (ACS),2018
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-361399
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361399URI
- https://doi.org/10.1021/acs.biomac.8b01484DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Herein, we report on the formation of cross-linked antimicrobial peptide-loaded microgel multilayers. Poly(ethyl acrylate- co-methacrylic acid) microgels were synthesized and functionalized with biotin to enable the formation of microgel multilayers cross-linked with avidin. Microgel functionalization and avidin cross-linking were verified with infrared spectroscopy, dynamic light scattering, and z-potential measurements, while multilayer formation (up to four layers) was studied with null ellipsometry and quartz crystal microbalance with dissipation (QCM-D). Incorporation of the antimicrobial peptide KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR) into the microgel multilayers was achieved either in one shot after multilayer formation or through addition after each microgel layer deposition. The latter was found to strongly promote peptide incorporation. Further, antimicrobial properties of the peptide-loaded microgel multilayers against Escherichia coli were investigated and compared to those of a peptide-loaded microgel monolayer. Results showed a more pronounced suppression in bacterial viability in suspension for the microgel multilayers. Correspondingly, LIVE/DEAD staining showed promoted disruption of adhered bacteria for the KYE28-loaded multilayers. Taken together, cross-linked microgel multilayers thus show promise as high load surface coatings for antimicrobial peptides.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- Pharmaceutical Physical Chemistry
- Farmaceutisk fysikalisk kemi
Added entries (persons, corporate bodies, meetings, titles ...)
- Al-Rammahi, NoorUppsala universitet,Institutionen för farmaci (author)
- Malekkhaiat Häffner, SaraUppsala universitet,Institutionen för farmaci(Swepub:uu)sarma170 (author)
- Strömstedt, Adam A.,Dr,1977-Uppsala universitet,Farmakognosi(Swepub:uu)adstr021 (author)
- Browning, Kathryn L.Uppsala universitet,Institutionen för farmaci(Swepub:uu)katbr474 (author)
- Malmsten, MartinUppsala universitet,Institutionen för farmaci(Swepub:uu)mamal991 (author)
- Uppsala universitetInstitutionen för farmaci (creator_code:org_t)
Related titles
- In:Biomacromolecules: American Chemical Society (ACS)19:12, s. 4691-47021525-77971526-4602
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