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HLA Class I and II ...
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Wang, Sophia S.City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
(author)
HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes
- Article/chapterEnglish2018
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-362009
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362009URI
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https://doi.org/10.1158/0008-5472.CAN-17-2900DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138766976URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 1.31, 95% CI = 1.06-1.60; OR MZL = 1.45, 95% CI = 1.12-1.89) and class II HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24-3.55; OR MZL = 2.10, 95% CI = 0.99-4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes. Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Carrington, MaryRagon Inst MGH MIT & Harvard, Cambridge, MA USA;Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Frederick, MD USA
(author)
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Berndt, Sonja I.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Slager, Susan L.Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
(author)
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Bracci, Paige M.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
(author)
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Voutsinas, JennaCity Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
(author)
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Cerhan, James R.Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
(author)
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Smedby, Karin E.Karolinska Institutet
(author)
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Hjalgrim, HenrikKarolinska Institutet
(author)
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Vijai, JosephMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
(author)
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Morton, Lindsay M.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Vermeulen, RoelUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
(author)
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Paltiel, OraHadassah Hebrew Univ Med Ctr, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel
(author)
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Vajdic, Claire M.Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia
(author)
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Linet, Martha S.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Nieters, AlexandraUniv Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Baden Wurttembe, Germany
(author)
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de Sanjose, SilviaCIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona 08908, Spain
(author)
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Cozen, WendyUniv Southern Calif, Dept Pathol, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
(author)
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Brown, Elizabeth E.Univ Alabama Birmingham, Sch Med, Dept Pathol, Birmingham, AL USA;Univ Alabama Birmingham, UAB Comprehens Canc Ctr, Birmingham, AL USA
(author)
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Turner, JenniferDouglass Hanly Moir Pathol, Dept Histopathol, Sydney, NSW, Australia;Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia
(author)
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Spinelli, John J.Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada;British Columbia Canc Agcy, Canc Control Res, Vancouver, BC, Canada
(author)
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Zheng, TongzhangBrown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA
(author)
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Birmann, Brenda M.Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Flowers, Christopher R.Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA
(author)
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Becker, NikolausGerman Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Baden Wurttembe, Germany
(author)
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Holly, Elizabeth A.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
(author)
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Kane, EleanorUniv York, Dept Hlth Sci, York, N Yorkshire, England
(author)
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Weisenburger, DennisCity Hope Natl Med Ctr, Dept Pathol, Duarte, CA USA
(author)
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Maynadie, MarcUniv Burgundy, INSERM, UMR1231, Registry Hematol Malignancies Cote Or, Dijon, France;Dijon Univ Hosp, Dijon, France
(author)
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Cocco, PierluigiUniv Cagliari, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy
(author)
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Albanes, DemetriusNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Weinstein, Stephanie J.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Teras, Lauren R.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
(author)
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Diver, W. RyanAmer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
(author)
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Lax, Stephanie J.Univ York, Dept Hlth Sci, York, N Yorkshire, England
(author)
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Travis, Ruth C.Univ Oxford, Canc Epidemiol Unit, Oxford, England
(author)
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Kaaks, RudolphGerman Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Baden Wurttembe, Germany
(author)
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Riboli, ElioImperial Coll London, Sch Publ Hlth, London, England
(author)
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Benavente, YolandaCIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona 08908, Spain
(author)
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Brennan, PaulInt Agcy Res Canc, Lyon, France
(author)
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McKay, JamesCHU Henri Mondor, Dept Immunol, Creteil, France
(author)
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Delfau-Larue, Marie-HeleneCHU Henri Mondor, INSERM, U955, Creteil, France;CHU Henri Mondor, Dept Immunol, Creteil, France
(author)
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Link, Brian K.Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
(author)
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Magnani, CorradoUniv Piemonte Orientale, Unit Med Stat & Epidemiol, Dept Translat Med, Novara, Italy;Univ Piemonte Orientale, Ctr Oncol Prevent CPO Piemonte, Novara, Italy
(author)
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Ennas, Maria GraziaUniv Cagliari, Dept Biomed Sci, Cagliari, Italy
(author)
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Latte, GiancarloS Francesco Hosp, Div Hematol, Nuoro, Italy
(author)
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Feldman, Andrew L.Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
(author)
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Doo, Nicole WongCanc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia
(author)
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Giles, Graham G.Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia
(author)
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Southey, Melissa C.Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia
(author)
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Milne, Roger L.Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia
(author)
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Offit, KennethRigshosp, Dept Hematol, Copenhagen, Denmark
(author)
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Musinsky, JacobRigshosp, Dept Hematol, Copenhagen, Denmark
(author)
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Arslan, Alan A.NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA;NYU, Dept Environm Med, Sch Med, 550 1St Ave, New York, NY 10016 USA;NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY USA
(author)
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Purdue, Mark P.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Adami, Hans-OlovKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(author)
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Melbye, MadsStanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA;Statens Serum Inst, Div Hlth Surveillance & Res, Dept Epidemiol Res, Copenhagen, Denmark
(author)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(author)
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Conde, LuciaUCL, UCL Canc Inst, Bill Lyons Informat Ctr, London, England
(author)
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Camp, Nicola J.Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA
(author)
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Glenn, MarthaUniv Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA
(author)
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Curtin, KarenUniv Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA
(author)
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Clavel, JacquelineUniv Paris 05, Paris, France;Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Epidemiol Childhood & Adolescent Canc Grp, INSERM, Paris, France
(author)
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Monnereau, AlainUniv Paris 05, Paris, France;Univ Bordeaux, Inst Bergonie, Registre Hemopathies Malignes Gironde, Inserm,Team EPICENE,UMR 1219, Bordeaux, France
(author)
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Cox, David G.Ctr Leon Berard, INSERM, UMR1052, Canc Res Ctr Lyon, Lyon, France. Ctr Leon Berard, Dept Hematol, Lyon, France;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
(author)
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Ghesquieres, HerveCNRS, UMR 5239, Lab Biol Mol Cellule, Pierre Benite, France;Univ Paris 05, Paris, France
(author)
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Salles, GillesCNRS, UMR 5239, Lab Biol Mol Cellule, Pierre Benite, France;Univ Claude Bernard Lyon, Lyon, France;Ctr Hosp Lyon Sud, Hosp Civils Lyon, Dept Hematol, Lyon, France
(author)
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Bofetta, PauloIcahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
(author)
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Foretova, LenkaMF MU, Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
(author)
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Staines, AnthonyDublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland
(author)
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Davis, ScottUniv Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA;Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA
(author)
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Severson, Richard K.Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA
(author)
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Lan, QingNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Brooks-Wilson, AngelaBC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada
(author)
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Smith, Martyn T.Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA
(author)
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Roman, EveUniv York, Dept Hlth Sci, York, N Yorkshire, England
(author)
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Kricker, AnneUniv Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia
(author)
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Zhang, YaweiYale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA;Yale Sch Med, Dept Surg, New Haven, CT USA
(author)
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Kraft, PeterHarvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
(author)
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Chanock, Stephen J.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Rothman, NathanielNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Hartge, PatriciaNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
(author)
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Skibola, Christine F.Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA
(author)
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City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USARagon Inst MGH MIT & Harvard, Cambridge, MA USA;Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Frederick, MD USA
(creator_code:org_t)
Related titles
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In:Cancer Research78:14, s. 4086-40960008-54721538-7445
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Wang, Sophia S.
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Carrington, Mary
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Berndt, Sonja I.
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Slager, Susan L.
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Bracci, Paige M.
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Voutsinas, Jenna
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Cerhan, James R.
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Smedby, Karin E.
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Hjalgrim, Henrik
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Vijai, Joseph
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Morton, Lindsay ...
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Vermeulen, Roel
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Paltiel, Ora
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Vajdic, Claire M ...
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Linet, Martha S.
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Nieters, Alexand ...
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de Sanjose, Silv ...
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Cozen, Wendy
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Brown, Elizabeth ...
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Turner, Jennifer
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Spinelli, John J ...
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Zheng, Tongzhang
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Birmann, Brenda ...
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Flowers, Christo ...
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Becker, Nikolaus
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Holly, Elizabeth ...
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Kane, Eleanor
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Weisenburger, De ...
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Maynadie, Marc
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Cocco, Pierluigi
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Albanes, Demetri ...
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Weinstein, Steph ...
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Teras, Lauren R.
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Diver, W. Ryan
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Lax, Stephanie J ...
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Travis, Ruth C.
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Kaaks, Rudolph
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Riboli, Elio
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Benavente, Yolan ...
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Brennan, Paul
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McKay, James
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Delfau-Larue, Ma ...
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Link, Brian K.
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Magnani, Corrado
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Ennas, Maria Gra ...
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Latte, Giancarlo
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Feldman, Andrew ...
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Doo, Nicole Wong
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Giles, Graham G.
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Southey, Melissa ...
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Milne, Roger L.
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Offit, Kenneth
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Musinsky, Jacob
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Arslan, Alan A.
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Purdue, Mark P.
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Adami, Hans-Olov
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Melbye, Mads
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Glimelius, Bengt
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Conde, Lucia
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Camp, Nicola J.
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Glenn, Martha
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Curtin, Karen
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Clavel, Jacqueli ...
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Monnereau, Alain
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Cox, David G.
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Ghesquieres, Her ...
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Salles, Gilles
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Bofetta, Paulo
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Foretova, Lenka
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Staines, Anthony
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Davis, Scott
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Severson, Richar ...
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Lan, Qing
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Brooks-Wilson, A ...
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Smith, Martyn T.
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Roman, Eve
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Kricker, Anne
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Zhang, Yawei
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Kraft, Peter
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Chanock, Stephen ...
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Rothman, Nathani ...
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Hartge, Patricia
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Skibola, Christi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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Cancer Research
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Uppsala University
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Karolinska Institutet