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Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia
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- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Asdahl, Peter H. (författare)
- Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark
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- Abrahamsson, Jonas (författare)
- Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden
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- Ha, Shau-Yin (författare)
- Queen Mary Hosp, Dept Pediat, Hong Kong, Hong Kong, Peoples R China;HKPHOSG, Hong Kong, Hong Kong, Peoples R China
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- Jonsson, Olafur G. (författare)
- Landspitali Univ Hosp, Dept Pediat, Reykjavik, Iceland
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- Kaspers, Gertjan J. L. (författare)
- Dutch Childhood Oncol Grp, The Hague, Netherlands;VU Univ Med Ctr Amsterdam, Dept Pediat, The Hague, Netherlands
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- Koskenvuo, Minna (författare)
- Univ Helsinki, Div Hematol Oncol & Stem Cell Transplantat, Childrens Hosp, Helsinki, Finland
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- Lausen, Birgitte (författare)
- Univ Copenhagen, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark
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- De Moerloose, Barbara (författare)
- Ghent Univ Hosp, Dept Pediat, Ghent, Belgium
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- Palle, Josefine, 1964- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Zeller, Bernward (författare)
- Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway
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- Hasle, Henrik (författare)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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(creator_code:org_t)
- 2018-05-21
- 2018
- Engelska.
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Ingår i: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 65:9
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BackgroundChildren with acute myeloid leukemia (AML) treated similarly show different toxicity and leukemic responses. We investigated associations between neutrophil recovery time after the first induction course, infection and relapse in children treated according to NOPHO-AML 2004 and DB AML-01. ProcedureNewly diagnosed patients with AML with bone marrow blast<5% between day 15 after the start of the treatment and the start of second induction course, and in complete remission after the second induction course were included (n=279). Neutrophil recovery time was defined as the time from the start of the course to the last day with absolute neutrophil count<0.5x10(9)/l. Linear and Cox regressions were used to investigate associations. ResultsNeutrophil recovery time after the first induction course was positively associated with neutrophil recovery time after the remaining courses, and longer neutrophil recovery time (25 days) was associated with increased risk of grade 3-4 infections (hazard ratio 1.4, 95% confidence interval [CI], 1.1-1.8). Longer neutrophil recovery time after the first induction (>30 days) was associated with the increased risk of relapse (5-year cumulative incidence: 48% vs. 42%, hazard ratio 1.7, 95% CI, 1.1-2.6) for cases not treated with hematopoietic stem cell transplantation in first complete remission. ConclusionLonger neutrophil recovery time after the first induction course was associated with grade 3-4 infections and relapse. If confirmed, this knowledge could be incorporated into risk stratification strategies in pediatric AML.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- acute myeloid leukemia
- infection
- neutropenia
- pediatric cancer
- relapse
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Abrahamsson, Jon ...
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Asdahl, Peter H.
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Abrahamsson, Jon ...
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Ha, Shau-Yin
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Jonsson, Olafur ...
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Kaspers, Gertjan ...
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visa fler...
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Koskenvuo, Minna
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Lausen, Birgitte
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De Moerloose, Ba ...
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Palle, Josefine, ...
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Zeller, Bernward
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Hasle, Henrik
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och Pediatrik
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Pediatric Blood ...
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Uppsala universitet
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Göteborgs universitet