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Safety of ticagrelo...
Safety of ticagrelor in patients with baseline conduction abnormalities : A PLATO (Study of Platelet Inhibition and Patient Outcomes) analysis
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- Scirica, Benjamin M. (författare)
- Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA
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- Bansilal, Sameer (författare)
- Icahn Sch Med Mt Sinai, Zena & Michael Weiner Cardiovasc Inst, New York, NY 10029 USA
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- Davoudi, Farideh (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA
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- Armstrong, Paul W. (författare)
- Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada
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- Clare, Robert M. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
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- Schulte, Phillip J. (författare)
- Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA;Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA;Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
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- Pieper, Karen S. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
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- Becker, Richard C. (författare)
- Univ Cincinnati, Coll Med, Heart Lung & Vasc Inst, Div Cardiovasc Hlth & Dis, Cincinnati, OH USA
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- James, Stefan K, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Storey, Robert F. (författare)
- Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England
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- Steg, Philippe Gabriel (författare)
- Imperial Coll, Royal Brompton Hosp, ICMS, NHLI, London, England;INSERM, U1148, F CRIN Network, FACT, Paris, France;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Paris, France;Paris Diderot Univ, Sorbonne Paris Cite, Paris, France
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- Held, Claes, 1956- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Himmelmann, Anders (författare)
- AstraZeneca Res & Dev, Gothenburg, Sweden
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- Mahaffey, Kenneth W. (författare)
- Stanford Univ, Dept Med, Sch Med, SCCR, Stanford, CA 94305 USA
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Cannon, Christopher P. (författare)
- Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 202, s. 54-60
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Although bradyarrhythmias have been observed with ticagrelor and its use with advanced atrioventricular block is not recommended, questions arise regarding its use in patients with mild conduction abnormalities. The objectives were to compare rates of clinically relevant arrhythmias in relation to any mild baseline conduction abnormality in patients with acute coronary syndrome randomized to ticagrelor versus clopidogrel. Methods: We included all subjects in the electrocardiographic (ECG) substudy of the Platelet Inhibition and Patient Outcomes trial, excluding those with missing baseline ECG or with a pacemaker at baseline (N = 15,460). Conduction abnormality was defined as sinus bradycardia, first-degree atrioventricular block, hemiblock, or bundle-branch block. The primary arrhythmic outcome was the composite of any symptomatic brady-or tachyarrhythmia, permanent pacemaker placement, or cardiac arrest through 12 months. Results: Patients with baseline conduction abnormalities (n = 4,256, 27.5%) were older and more likely to experience the primary arrhythmic outcome. There were no differences by ticagrelor versus clopidogrel in the composite arrhythmic end point in those with baseline conduction disease (1-year cumulative incidence rate: 17% for both study arms; hazard ratio: 0.99 [0.86-1.15]) or without baseline conduction disease (1-year cumulative incidence rate: clopidogrel 12.8% vs ticagrelor 12.4%; hazard ratio: 0.98 (0.88-1.09). There were also no statistically significant differences between ticagrelor and clopidogrel in the rates of bradycardic (or any individual arrhythmic) events in patients with baseline conduction abnormalities. Conclusions: Ticagrelor compared to clopidogrel did not increase arrhythmic events even in subjects with acute coronary syndrome who present with mild conduction abnormalities on their baseline ECG. (C) 2018 Published by Elsevier Inc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Scirica, Benjami ...
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Bansilal, Sameer
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Davoudi, Farideh
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Armstrong, Paul ...
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Clare, Robert M.
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Schulte, Phillip ...
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Pieper, Karen S.
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Becker, Richard ...
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James, Stefan K, ...
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Storey, Robert F ...
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Steg, Philippe G ...
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Held, Claes, 195 ...
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Himmelmann, Ande ...
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Mahaffey, Kennet ...
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Wallentin, Lars, ...
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Cannon, Christop ...
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