SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Seeck Margitta)
 

Sökning: WFRF:(Seeck Margitta) > Nicotinic receptor ...

  • Garibotto, ValentinaUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, Switzerland (författare)

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2018-09-29
  • Springer Science and Business Media LLC,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-362194
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362194URI
  • https://doi.org/10.1007/s00259-018-4175-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [18F]-fluorodeoxyglucose (FDG), 3D T1 MRI and diffusion tensor imaging (DTI). F-A-85380 and FDG images were compared with the control group using a voxel-wise (SPM12) and a volumes of interest (VOI) analysis.Results: In the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BPRI, corresponding to the receptor availability) in the anterior cingulate cortex (ACC), without structural changes on MRI. At an individual level, F-A-85380 BPRI increase in the ACC could distinguish IGE patients from controls and from patients with focal epilepsy with good accuracy.Conclusions: We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wissmeyer, MichaelUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland (författare)
  • Giavri, ZoiAdvantis Med Imaging, Eindhoven, Netherlands (författare)
  • Goldstein, RachelUniv Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland (författare)
  • Seimbille, YannUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland (författare)
  • Seeck, MargittaUniv Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland (författare)
  • Ratib, OsmanUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland (författare)
  • Haller, SvenUppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland; CIRD, Geneva, Switzerland(Swepub:uu)sveha228 (författare)
  • Picard, FabienneUniv Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland (författare)
  • Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, SwitzerlandUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC46:2, s. 385-3951619-70701619-7089

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy