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Nicotinic receptor ...
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Garibotto, ValentinaUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, Switzerland
(författare)
Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2018-09-29
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Springer Science and Business Media LLC,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-362194
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362194URI
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https://doi.org/10.1007/s00259-018-4175-0DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [18F]-fluorodeoxyglucose (FDG), 3D T1 MRI and diffusion tensor imaging (DTI). F-A-85380 and FDG images were compared with the control group using a voxel-wise (SPM12) and a volumes of interest (VOI) analysis.Results: In the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BPRI, corresponding to the receptor availability) in the anterior cingulate cortex (ACC), without structural changes on MRI. At an individual level, F-A-85380 BPRI increase in the ACC could distinguish IGE patients from controls and from patients with focal epilepsy with good accuracy.Conclusions: We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wissmeyer, MichaelUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
(författare)
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Giavri, ZoiAdvantis Med Imaging, Eindhoven, Netherlands
(författare)
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Goldstein, RachelUniv Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
(författare)
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Seimbille, YannUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
(författare)
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Seeck, MargittaUniv Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
(författare)
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Ratib, OsmanUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
(författare)
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Haller, SvenUppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland; CIRD, Geneva, Switzerland(Swepub:uu)sveha228
(författare)
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Picard, FabienneUniv Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
(författare)
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Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, SwitzerlandUniv Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC46:2, s. 385-3951619-70701619-7089
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